Nonpermissive allele mismatch combinations for severe aGVHD
| Mismatch combination, donor-patient . | N . | HR (95% CI) . | P . |
|---|---|---|---|
| A0206-A0201 | 131 | 1.78 (1.32-2.41) | < .001 |
| A0206-A0207 | 27 | 3.45 (2.09-5.70) | < .001 |
| A2602-A2601 | 21 | 3.35 (1.89-5.91) | < .001 |
| A2603-A2601 | 35 | 2.17 (1.29-3.64) | .003 |
| B1501-B1507 | 19 | 3.34 (1.85-5.99) | < .001 |
| C0303-C1502 | 25 | 3.22 (1.75-5.89) | < .001 |
| C0304-C0801 | 69 | 2.34 (1.55-3.52) | < .001 |
| C0401-C0303 | 42 | 2.81 (1.72-4.60) | < .001 |
| C0801-C0303 | 80 | 2.32 (1.58-3.40) | < .001 |
| C1402-C0304 | 23 | 3.66 (2.00-6.68) | < .001 |
| C1502-C0304 | 27 | 3.77 (2.20-6.47) | < .001 |
| C1502-C1402 | 50 | 4.97 (3.41-7.25) | < .001 |
| DR0405-DR0403 | 53 | 2.13 (1.28-3.53) | .003 |
| (DR1403-DQ0301)-(DR1401-DQ0502) | 19 | 2.81 (1.44-5.51) | .002 |
| DP0301-DP0501 | 49 | 2.41 (1.49-3.89) | < .001 |
| DP0501-DP0901 | 71 | 2.03 (1.30-3.16) | .002 |
| Mismatch combination, donor-patient . | N . | HR (95% CI) . | P . |
|---|---|---|---|
| A0206-A0201 | 131 | 1.78 (1.32-2.41) | < .001 |
| A0206-A0207 | 27 | 3.45 (2.09-5.70) | < .001 |
| A2602-A2601 | 21 | 3.35 (1.89-5.91) | < .001 |
| A2603-A2601 | 35 | 2.17 (1.29-3.64) | .003 |
| B1501-B1507 | 19 | 3.34 (1.85-5.99) | < .001 |
| C0303-C1502 | 25 | 3.22 (1.75-5.89) | < .001 |
| C0304-C0801 | 69 | 2.34 (1.55-3.52) | < .001 |
| C0401-C0303 | 42 | 2.81 (1.72-4.60) | < .001 |
| C0801-C0303 | 80 | 2.32 (1.58-3.40) | < .001 |
| C1402-C0304 | 23 | 3.66 (2.00-6.68) | < .001 |
| C1502-C0304 | 27 | 3.77 (2.20-6.47) | < .001 |
| C1502-C1402 | 50 | 4.97 (3.41-7.25) | < .001 |
| DR0405-DR0403 | 53 | 2.13 (1.28-3.53) | .003 |
| (DR1403-DQ0301)-(DR1401-DQ0502) | 19 | 2.81 (1.44-5.51) | .002 |
| DP0301-DP0501 | 49 | 2.41 (1.49-3.89) | < .001 |
| DP0501-DP0901 | 71 | 2.03 (1.30-3.16) | .002 |
Analysis method is the same as in Table 1. We surveyed specific linked mismatches between nonpermissive mismatches elucidated. As a result, obvious specific linked mismatches exist only between DRB1*1403- DRB1*1401 and DQB1*0301- DQB1*0502. Therefore, we could not evaluate which mismatch combination impacted aGVHD, and we considered this linked mismatch did so. On the other hand, because other nonpermissive mismatch combinations had no specific link with the others, we judged other than DRB1*1403- DRB1*1401 and DQB1*0301- DQB1*0502 nonpermissive mismatches solely impacted aGVHD. (DR1403-DQ0301)-(DR1401-DQ0502) linked mismatch meant that the donor has HLA-DRB1*1403-HLADQB1*0301 and the recipient has HLA-DRB1*1401-HLADQB1*0502.
HR indicates hazard ratio; CI, confidence interval.