Multivariable analysis of impact of number of nonpermissive mismatches on severe aGVHD and overall survival
| . | N . | Event* . | Univariate analysis . | Multivariate analysis . | Bootstrap (10000) . | |||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |||
| For severe aGVHD | ||||||||
| Full match group | 972 | 129 | 1.00 | NA | 1.00 | NA | 1.00 | NA |
| Zero nonpermissive mismatch group | 2446 | 411 | 1.21 (0.95-1.54) | .111 | 1.00 (0.75-1.32) | .996 | 1.00 (0.74-1.33) | .996 |
| One nonpermissive mismatch group | 571 | 211 | 2.88 (2.20-3.78) | < .001 | 2.22 (1.62-3.04) | < .001 | 2.22 (1.63-3.02) | < .001 |
| Two or more nonpermissive mismatch group | 61 | 36 | 5.62 (3.77-8.39) | < .001 | 3.68 (2.33-5.80) | < .001 | 3.68 (2.33-5.80) | < .001 |
| For overall survival | ||||||||
| Full match group | 972 | 400 | 1.00 | NA | 1.00 | NA | 1.00 | NA |
| Zero nonpermissive mismatch group | 2446 | 1021 | 1.10 (0.98-1.23) | .091 | 1.06 (0.94-1.20) | .315 | 1.06 (0.94-1.20) | .299 |
| One nonpermissive mismatch group | 571 | 309 | 1.55 (1.34-1.78) | < .001 | 1.51 (1.30-1.76) | < .001 | 1.51 (1.29-1.77) | < .001 |
| Two or more nonpermissive mismatch group | 61 | 39 | 2.12 (1.54-2.90) | < .001 | 2.25 (1.65-3.08) | < .001 | 2.25 (1.65-3.08) | < .001 |
| . | N . | Event* . | Univariate analysis . | Multivariate analysis . | Bootstrap (10000) . | |||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |||
| For severe aGVHD | ||||||||
| Full match group | 972 | 129 | 1.00 | NA | 1.00 | NA | 1.00 | NA |
| Zero nonpermissive mismatch group | 2446 | 411 | 1.21 (0.95-1.54) | .111 | 1.00 (0.75-1.32) | .996 | 1.00 (0.74-1.33) | .996 |
| One nonpermissive mismatch group | 571 | 211 | 2.88 (2.20-3.78) | < .001 | 2.22 (1.62-3.04) | < .001 | 2.22 (1.63-3.02) | < .001 |
| Two or more nonpermissive mismatch group | 61 | 36 | 5.62 (3.77-8.39) | < .001 | 3.68 (2.33-5.80) | < .001 | 3.68 (2.33-5.80) | < .001 |
| For overall survival | ||||||||
| Full match group | 972 | 400 | 1.00 | NA | 1.00 | NA | 1.00 | NA |
| Zero nonpermissive mismatch group | 2446 | 1021 | 1.10 (0.98-1.23) | .091 | 1.06 (0.94-1.20) | .315 | 1.06 (0.94-1.20) | .299 |
| One nonpermissive mismatch group | 571 | 309 | 1.55 (1.34-1.78) | < .001 | 1.51 (1.30-1.76) | < .001 | 1.51 (1.29-1.77) | < .001 |
| Two or more nonpermissive mismatch group | 61 | 39 | 2.12 (1.54-2.90) | < .001 | 2.25 (1.65-3.08) | < .001 | 2.25 (1.65-3.08) | < .001 |
Each group was compared with Full match group. Confounders considered were sex (donor-recipient pairs), patient age (linear), donor age (linear), type of disease, risk of leukemia relapse (standard, highand diseases other than leukemia), GVHD prophylaxis, (CSP vs. FK), ATG (ATG vs. no ATG) and preconditioning (TBI vs. non-TBI).
HR indicates hazard ratio; CI, confidence interval; Boot strap (10000), bootstrap resampling using 10000 bootstrapping.
For severe aGVHD, “Event” refers to number of occurrences; for overall survival, number of deaths.