Summary of the strength of associations in the network
| Variable* . | Effect, OR . | Effect, OR . | Referent group . |
|---|---|---|---|
| ACS | 1.18 (1.14;1.24) | † | No ACS |
| Age, y | 2.67 (2.44;2.91) [18-40] | 7.61 (5.11;1.34) [>40] | 2-18 years |
| Bilirubin level | 1.43 (1.28;1.60) [1.3-3.4] | 1.59 (1.02;2.49) [>3.4] | Normal |
| Blood transfusion | 2.01 (1.78;2.27) | † | No chronic BT |
| LDH level | 0.85 (0.76;0.94) [<300] | 1.1 (0.99;1.24) [>600] | Normal |
| MCV | 0.54 (0.49;0.60) [<80] | 1.98 (1.71; 2.29) [>98] | Normal |
| Pain | 1.61 (1.45;1.77) | † | No pain |
| Priapism | 1.35 (1.09;1.67) | † | No priapism |
| Reticulocyte count | 0.5 (0.44;0.55) [<4.8] | 1.51 (1.39;1.65) [>13] | Normal |
| Sepsis | 67.19 (57.66;78.29) | † | No sepsis |
| Sex | 1.16 (1.08;1.25) | † | Females |
| Stroke | 3.81 (3.20;4.54) | † | No stroke |
| Sys BP | 2.84 (1.67;4.82) [low] | 3.41 (2.71;4.27) [high] | Normal |
| WBC count | 1.37 (1.24;1.51) [10.8-13.5] | 1.92 (1.44;2.55) [>13.5] | Normal |
| Variable* . | Effect, OR . | Effect, OR . | Referent group . |
|---|---|---|---|
| ACS | 1.18 (1.14;1.24) | † | No ACS |
| Age, y | 2.67 (2.44;2.91) [18-40] | 7.61 (5.11;1.34) [>40] | 2-18 years |
| Bilirubin level | 1.43 (1.28;1.60) [1.3-3.4] | 1.59 (1.02;2.49) [>3.4] | Normal |
| Blood transfusion | 2.01 (1.78;2.27) | † | No chronic BT |
| LDH level | 0.85 (0.76;0.94) [<300] | 1.1 (0.99;1.24) [>600] | Normal |
| MCV | 0.54 (0.49;0.60) [<80] | 1.98 (1.71; 2.29) [>98] | Normal |
| Pain | 1.61 (1.45;1.77) | † | No pain |
| Priapism | 1.35 (1.09;1.67) | † | No priapism |
| Reticulocyte count | 0.5 (0.44;0.55) [<4.8] | 1.51 (1.39;1.65) [>13] | Normal |
| Sepsis | 67.19 (57.66;78.29) | † | No sepsis |
| Sex | 1.16 (1.08;1.25) | † | Females |
| Stroke | 3.81 (3.20;4.54) | † | No stroke |
| Sys BP | 2.84 (1.67;4.82) [low] | 3.41 (2.71;4.27) [high] | Normal |
| WBC count | 1.37 (1.24;1.51) [10.8-13.5] | 1.92 (1.44;2.55) [>13.5] | Normal |
The second and third columns report, for each variable in column 1, the marginal effect on the disease severity score measured by the odds ratio for death within 5 years, and 95% confidence intervals in parentheses. Names in square brackets describe the category compared with the referent group when the variable has more than 2 categories: for example 2.67 in column 2, row 2, are the odds for death in 5 years of a subject aged between 18 and 40 years, compared with a subject less than age 18 years. Note that the effect of each variable changes when the other variables change (see Table 5).
Variables sufficient to compute the disease severity score.
When the variable has only 2 categories, column 2 reports the odds for death in 5 years compared with the referent group in column 4.