Frequency of nonhematologic toxicities (drug-related, first course)
| VPA dose* . | No. with toxicity . | ||||
|---|---|---|---|---|---|
| No. . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| 50 mg/kg | 6 | 1 | 4 | 1 | 0 |
| 62.5 mg/kg | 7 | 0 | 5 | 2 | 0 |
| 75 mg/kg | 6 | 1 | 3 | 2 | 0 |
| Phase 2, 50 mg/kg | 34 | 5 | 14 | 6 | 2 |
| VPA dose* . | No. with toxicity . | ||||
|---|---|---|---|---|---|
| No. . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| 50 mg/kg | 6 | 1 | 4 | 1 | 0 |
| 62.5 mg/kg | 7 | 0 | 5 | 2 | 0 |
| 75 mg/kg | 6 | 1 | 3 | 2 | 0 |
| Phase 2, 50 mg/kg | 34 | 5 | 14 | 6 | 2 |
Daily for 7 days.