Composition of the miRNA signature of cHL
| miRNA . | Chromosomal location . | Expression level . | Putative targets* . |
|---|---|---|---|
| miR-21 | 17q23.2 | High | PTEN,† TPM1,† TRAIL-3, |
| miR-23b | 9q22.32 | Low | NOTCH1,† SUMO1, PLK3, POU4F2 |
| miR-26b | 2q35 | Low | MMP21, IFNG |
| miR-27a | 19p13.12 | High | CD44 |
| miR-30b | 8q24.22 | Low | CCNE1, ITGB3, ITGA5, TIMP-2, TIMP-3, SERPINE1 |
| miR-31 | 9p21.3 | Low | CD28, CD48, EBF3, TRAF3 |
| miR-124a | 8p23.1 | High | ITGB1,† ANGPT1† |
| miR-126 | 9q34.3 | Low | CD97, BAD, IKBKAP, VCAM1, TNFC, TNFS11, PIK3C |
| miR-134 | 14q32.31 | High | J-CHAIN |
| miR-135a | 3p21.2 | Low | MSH2 |
| miR-138 | 7q32.2 | High | PU.1, TCF3, E2A, FAK, HIF-1A |
| miR-147 | 9q32.2 | High | NOL3, ZAP-70 |
| miR-182* | 7q32.2 | High | NA |
| miR-183 | 7q32.2 | Low | ITGB1 |
| miR-185 | 22q11.21 | High | PBX1, CD79B |
| miR-198 | 3q13.33 | High | CCND2, BCL7A |
| miR-204 | 9q21.13 | Low | ATF2, BCL2, CDC25B, BCL9, BCL11A, BCL11B |
| miR-205 | 1q32.2 | Low | K-RAS, SMAD4, MSH2, PTEN |
| miR-216 | 2p16.1 | High | BCL11B, BCL9 |
| miR-220 | Xq25 | High | IRF3 |
| miR-302a | 4q25 | High | CD45, CD138, RECK, CXCR4 |
| miR-302b | 4q25 | High | CD45, CD138, RECK, CXCR4 |
| miR-302c | 4q25 | High | CD45, CD138, RECK, CXCR4 |
| miR-325 | Xq21.1 | High | NFkB-REPRESOR FACTOR |
| miR-335 | 7q32.2 | Low | ANGPT1 |
| miRNA . | Chromosomal location . | Expression level . | Putative targets* . |
|---|---|---|---|
| miR-21 | 17q23.2 | High | PTEN,† TPM1,† TRAIL-3, |
| miR-23b | 9q22.32 | Low | NOTCH1,† SUMO1, PLK3, POU4F2 |
| miR-26b | 2q35 | Low | MMP21, IFNG |
| miR-27a | 19p13.12 | High | CD44 |
| miR-30b | 8q24.22 | Low | CCNE1, ITGB3, ITGA5, TIMP-2, TIMP-3, SERPINE1 |
| miR-31 | 9p21.3 | Low | CD28, CD48, EBF3, TRAF3 |
| miR-124a | 8p23.1 | High | ITGB1,† ANGPT1† |
| miR-126 | 9q34.3 | Low | CD97, BAD, IKBKAP, VCAM1, TNFC, TNFS11, PIK3C |
| miR-134 | 14q32.31 | High | J-CHAIN |
| miR-135a | 3p21.2 | Low | MSH2 |
| miR-138 | 7q32.2 | High | PU.1, TCF3, E2A, FAK, HIF-1A |
| miR-147 | 9q32.2 | High | NOL3, ZAP-70 |
| miR-182* | 7q32.2 | High | NA |
| miR-183 | 7q32.2 | Low | ITGB1 |
| miR-185 | 22q11.21 | High | PBX1, CD79B |
| miR-198 | 3q13.33 | High | CCND2, BCL7A |
| miR-204 | 9q21.13 | Low | ATF2, BCL2, CDC25B, BCL9, BCL11A, BCL11B |
| miR-205 | 1q32.2 | Low | K-RAS, SMAD4, MSH2, PTEN |
| miR-216 | 2p16.1 | High | BCL11B, BCL9 |
| miR-220 | Xq25 | High | IRF3 |
| miR-302a | 4q25 | High | CD45, CD138, RECK, CXCR4 |
| miR-302b | 4q25 | High | CD45, CD138, RECK, CXCR4 |
| miR-302c | 4q25 | High | CD45, CD138, RECK, CXCR4 |
| miR-325 | Xq21.1 | High | NFkB-REPRESOR FACTOR |
| miR-335 | 7q32.2 | Low | ANGPT1 |
The putative targets shown were selected based on functional aspects (David Database) and on described gene associations (GENIG).
NA indicates not applicable.
Putative target genes identified from Mirbase and TargetScan using DAVID database and GENIG software.
Target genes experimentally validated were identified from Tarbase.