Differentially expressed genes in MYC+BCL2+ de novo DLBCL
| Gene functional categories . | No. of genes . | Representative genes . |
|---|---|---|
| Downregulated genes | ||
| ECM, ECM production and remodeling | 33 | COL3A1, VCAN, TNS1, FN1, THBS2, TIMP3, SPARC, SULF1, SPINK2, MMP2, ADAM12, FGFR1, FAP |
| Cell adhesion and cytoskeletal organization | 21 | CD11A/CD11B, CD58, THY1, RFTN1, ANTXR1, RHOB, MICAL2 |
| Cell growth regulation | 16 | LM02, TRAF1, CDK14,SGK1, RGS1, NBL, PDE4D |
| Others, including unknown | 18 | PSAP, LYZ, LOC115110, ZNF662 |
| Upregulated genes | ||
| Cell proliferation | 20 | MYC, BCL2, TCL1A, MLL, FOXP1, SPIB, TCF4, TNFRSF13B, PMDAIP1, GAB1, PLOR3G |
| Cell metabolism | 5 | DCTPP1, CYB5R2, HK2,TMEM97, CYB5R2 |
| Miscellaneous cell functions | 13 | PPIL1, PIGW, FUT8, SPINK5 |
| Unknown | 27 | KIAA0664, C9orf91, ZNF107 |
| Gene functional categories . | No. of genes . | Representative genes . |
|---|---|---|
| Downregulated genes | ||
| ECM, ECM production and remodeling | 33 | COL3A1, VCAN, TNS1, FN1, THBS2, TIMP3, SPARC, SULF1, SPINK2, MMP2, ADAM12, FGFR1, FAP |
| Cell adhesion and cytoskeletal organization | 21 | CD11A/CD11B, CD58, THY1, RFTN1, ANTXR1, RHOB, MICAL2 |
| Cell growth regulation | 16 | LM02, TRAF1, CDK14,SGK1, RGS1, NBL, PDE4D |
| Others, including unknown | 18 | PSAP, LYZ, LOC115110, ZNF662 |
| Upregulated genes | ||
| Cell proliferation | 20 | MYC, BCL2, TCL1A, MLL, FOXP1, SPIB, TCF4, TNFRSF13B, PMDAIP1, GAB1, PLOR3G |
| Cell metabolism | 5 | DCTPP1, CYB5R2, HK2,TMEM97, CYB5R2 |
| Miscellaneous cell functions | 13 | PPIL1, PIGW, FUT8, SPINK5 |
| Unknown | 27 | KIAA0664, C9orf91, ZNF107 |