VcR-CVAD induction: grade 3-4 toxicities* (% patients), n = 75
| . | Grade 3, % . | Grade 4, % . |
|---|---|---|
| Hematologic | ||
| Neutropenia | 15 | 69 |
| Hemoglobin | 32 | 1 |
| Platelets | 23 | 44 |
| Neutropenic fever | 8 | 3 |
| Neutropenic infection | 5 | 1 |
| Infection without grade 3-4 neutropenia | 7 | 1 |
| Fatigue | 9 | 1 |
| Anorexia | 5 | – |
| Nausea | 1 | – |
| Vomiting | 1 | – |
| Constipation | 1 | – |
| Diarrhea | 4 | – |
| Dehydration | 4 | – |
| Mucositis/stomatitis | 3 | – |
| Abdominal pain | 4 | – |
| Dyspnea | 3 | – |
| Thrombosis/embolism | 3 | 1 |
| Hyperglycemia | 9 | – |
| . | Grade 3, % . | Grade 4, % . |
|---|---|---|
| Hematologic | ||
| Neutropenia | 15 | 69 |
| Hemoglobin | 32 | 1 |
| Platelets | 23 | 44 |
| Neutropenic fever | 8 | 3 |
| Neutropenic infection | 5 | 1 |
| Infection without grade 3-4 neutropenia | 7 | 1 |
| Fatigue | 9 | 1 |
| Anorexia | 5 | – |
| Nausea | 1 | – |
| Vomiting | 1 | – |
| Constipation | 1 | – |
| Diarrhea | 4 | – |
| Dehydration | 4 | – |
| Mucositis/stomatitis | 3 | – |
| Abdominal pain | 4 | – |
| Dyspnea | 3 | – |
| Thrombosis/embolism | 3 | 1 |
| Hyperglycemia | 9 | – |
Toxicities reported are worst-grade toxicities per patient during the induction period among eligible patients.