Table 3

Survival and blood counts of primary and secondary AMLs

MouseDonor cellsDays*SpleenWBC (K/µL)RBC (M/µL)Hb (g/dL)PLT (K/µL)
Controls (n = 4) Egr1+/−, Apcdel/+ BM + Luc shRNA 420 0.1 g 9.9 ± 1.4 7.8 ± 0.9 10.6 ± 1.5 1377 ± 77 
Primary        
 1586 Egr1+/−, Apcdel/+ BM + Tp53 shRNA 234 0.3 g 182.4 3.5 7.4 572 
 4525 Egr1+/−, Apcdel/+ BM + Tp53 shRNA 299 0.3 g 22.2 4.8 8.7 344 
Secondary        
 6751 1586 spleen Alive†      
 6752 1586 spleen Alive      
 6753 1586 spleen 111 1.6 g 68.4 2.6 5.4 275 
 6754 1586 spleen Alive      
 6755 4525 spleen 49 0.4 g 69.4 8.0 10.5 264 
 6756 4525 spleen 57 0.2 g 10.0 11.2 14.6 488 
 6767 4525 spleen 40 0.3 g 6.5 7.9 9.7 196 
MouseDonor cellsDays*SpleenWBC (K/µL)RBC (M/µL)Hb (g/dL)PLT (K/µL)
Controls (n = 4) Egr1+/−, Apcdel/+ BM + Luc shRNA 420 0.1 g 9.9 ± 1.4 7.8 ± 0.9 10.6 ± 1.5 1377 ± 77 
Primary        
 1586 Egr1+/−, Apcdel/+ BM + Tp53 shRNA 234 0.3 g 182.4 3.5 7.4 572 
 4525 Egr1+/−, Apcdel/+ BM + Tp53 shRNA 299 0.3 g 22.2 4.8 8.7 344 
Secondary        
 6751 1586 spleen Alive†      
 6752 1586 spleen Alive      
 6753 1586 spleen 111 1.6 g 68.4 2.6 5.4 275 
 6754 1586 spleen Alive      
 6755 4525 spleen 49 0.4 g 69.4 8.0 10.5 264 
 6756 4525 spleen 57 0.2 g 10.0 11.2 14.6 488 
 6767 4525 spleen 40 0.3 g 6.5 7.9 9.7 196 
*

Refers to the number of days posttransplant, before the mouse appeared moribund and was euthanized.

†

Alive refers to animals that remain disease-free at ∼170 days posttransplant.

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