Paired analyses comparing the prevalence and transcript levels of gametocyte stage markers between bone marrow and peripheral blood
| . | Prevalence . | Relative transcript copy number* . | ||||||
|---|---|---|---|---|---|---|---|---|
| . | Peripheral blood . | Bone marrow–Peripheral blood . | ||||||
| Bone marrow . | Positive . | Negative . | P† . | n > 0‡ . | n < 0‡ . | Median§ . | Interquartile range . | P¶ . |
| Early | ||||||||
| Positive | 3 | 13 | <.001 | 15 | 1 | 0.098 | 0.043, 0.295 | .004 |
| Negative | 0 | 0 | ||||||
| Intermediate | ||||||||
| Positive | 3 | 13 | <.001 | 16 | 0 | 0.210 | 0.034, 1.696 | <.001 |
| Negative | 0 | 0 | ||||||
| Mature | ||||||||
| Positive | 15 | 0 | .032 | 10 | 6 | 0.110 | −0.047, 1.539 | .148 |
| Negative | 1 | 0 | ||||||
| . | Prevalence . | Relative transcript copy number* . | ||||||
|---|---|---|---|---|---|---|---|---|
| . | Peripheral blood . | Bone marrow–Peripheral blood . | ||||||
| Bone marrow . | Positive . | Negative . | P† . | n > 0‡ . | n < 0‡ . | Median§ . | Interquartile range . | P¶ . |
| Early | ||||||||
| Positive | 3 | 13 | <.001 | 15 | 1 | 0.098 | 0.043, 0.295 | .004 |
| Negative | 0 | 0 | ||||||
| Intermediate | ||||||||
| Positive | 3 | 13 | <.001 | 16 | 0 | 0.210 | 0.034, 1.696 | <.001 |
| Negative | 0 | 0 | ||||||
| Mature | ||||||||
| Positive | 15 | 0 | .032 | 10 | 6 | 0.110 | −0.047, 1.539 | .148 |
| Negative | 1 | 0 | ||||||
n = 16 paired samples.
Ratio between copy numbers of gametocyte transcripts and P falciparum ubiquitin-conjugating enzyme transcript.
Prevalences were compared using the McNemar test.
Number of pairs showing a higher (n > 0) or lower (n < 0) copy number of transcripts in bone marrow compared with peripheral blood.
Median of the difference.
Relative transcript copy numbers were compared using the Wilcoxon signed-rank test.