Phenotype of human ILCs
| . | NK cells . | ILC1 . | ILC2 . | ILC3 . | |||
|---|---|---|---|---|---|---|---|
| CD127− . | CD127− . | CD127+ . | LTi . | NKp44− . | NKp44+ . | ||
| Lin | − | − | − | − | − | − | − |
| CD7 | + | + | + | + | + | + | |
| CD16 | +/− | − | − | − | − | − | − |
| CD25 | +/− | − | + | + | − | ||
| CD56 | + | + | − | − | − | − | +/− |
| CD94 | + | − | − | − | − | − | − |
| CD103 | + | − | |||||
| CD117 (cKit) | − | − | +/− | low | + | + | |
| CD127 | − | − | + | + | + | + | + |
| CD161 | +/− | + | + | +/− | + | + | |
| CCR6 | − | + | + | + | + | + | |
| CRTH2 | − | − | + | − | − | − | |
| ICOS | + | ||||||
| IL1bR | − | − | + | + | + | + | + |
| IL12RB | + | + | − | − | − | +/− | |
| IL15RA | + | + | − | ||||
| IL17RB | − | − | + | − | − | ||
| IL23R | − | +/− | − | + | + | + | |
| MHC-II | +/− | +/− | +/− | ||||
| NKp44 | +/− | + | − | − | − | − | + |
| NKp46 | + | + | − | − | low | low | |
| ST2 | +/− | − | + | − | − | ||
| . | NK cells . | ILC1 . | ILC2 . | ILC3 . | |||
|---|---|---|---|---|---|---|---|
| CD127− . | CD127− . | CD127+ . | LTi . | NKp44− . | NKp44+ . | ||
| Lin | − | − | − | − | − | − | − |
| CD7 | + | + | + | + | + | + | |
| CD16 | +/− | − | − | − | − | − | − |
| CD25 | +/− | − | + | + | − | ||
| CD56 | + | + | − | − | − | − | +/− |
| CD94 | + | − | − | − | − | − | − |
| CD103 | + | − | |||||
| CD117 (cKit) | − | − | +/− | low | + | + | |
| CD127 | − | − | + | + | + | + | + |
| CD161 | +/− | + | + | +/− | + | + | |
| CCR6 | − | + | + | + | + | + | |
| CRTH2 | − | − | + | − | − | − | |
| ICOS | + | ||||||
| IL1bR | − | − | + | + | + | + | + |
| IL12RB | + | + | − | − | − | +/− | |
| IL15RA | + | + | − | ||||
| IL17RB | − | − | + | − | − | ||
| IL23R | − | +/− | − | + | + | + | |
| MHC-II | +/− | +/− | +/− | ||||
| NKp44 | +/− | + | − | − | − | − | + |
| NKp46 | + | + | − | − | low | low | |
| ST2 | +/− | − | + | − | − | ||
ILCs are categorized into CD127− NK cells, CD127− ILC1s and CD127+ ILC1s, ILC2s, and ILC3s, the latter including LTi, NCR− ILCs, and NCR+ ILC3s. +/− denotes expression that is upregulated by ILCs after activation or by a nonactivated subset of ILCs.