Signature cytokines of human ILCs
| . | NK cells . | ILC1 . | ILC2 . | ILC3 . | |||
|---|---|---|---|---|---|---|---|
| CD127− . | CD127− . | CD127+ . | LTi . | NKp44− . | NKp44+ . | ||
| Amphiregulin | − | − | − | + | − | − | − |
| BAFF | + | ||||||
| CSF1 | + | ||||||
| GM-CSF | +/− | + | + | ||||
| Granzyme | + | + | − | − | − | − | − |
| IFN-γ | + | + | + | − | − | − | − |
| IL-2 | + | ||||||
| IL-3 | + | ||||||
| IL-4 | − | − | + | − | − | − | |
| IL-5 | − | − | + | − | − | − | |
| IL-8 | + | ||||||
| IL-9 | − | − | + | − | − | − | |
| IL-13 | − | − | + | − | − | +/− | |
| IL-17 | − | − | − | + | + | − | |
| IL-21 | + | ||||||
| IL-22 | − | − | +/− | − | + | + | |
| LTα | − | + | |||||
| LTβ | − | + | |||||
| Perforin | + | + | − | − | − | − | − |
| TNFα | + | ||||||
| . | NK cells . | ILC1 . | ILC2 . | ILC3 . | |||
|---|---|---|---|---|---|---|---|
| CD127− . | CD127− . | CD127+ . | LTi . | NKp44− . | NKp44+ . | ||
| Amphiregulin | − | − | − | + | − | − | − |
| BAFF | + | ||||||
| CSF1 | + | ||||||
| GM-CSF | +/− | + | + | ||||
| Granzyme | + | + | − | − | − | − | − |
| IFN-γ | + | + | + | − | − | − | − |
| IL-2 | + | ||||||
| IL-3 | + | ||||||
| IL-4 | − | − | + | − | − | − | |
| IL-5 | − | − | + | − | − | − | |
| IL-8 | + | ||||||
| IL-9 | − | − | + | − | − | − | |
| IL-13 | − | − | + | − | − | +/− | |
| IL-17 | − | − | − | + | + | − | |
| IL-21 | + | ||||||
| IL-22 | − | − | +/− | − | + | + | |
| LTα | − | + | |||||
| LTβ | − | + | |||||
| Perforin | + | + | − | − | − | − | − |
| TNFα | + | ||||||
ILCs are categorized into CD127− NK cells, CD127− ILC1s and CD127+ ILC1s, ILC2s, and ILC3s, the latter including LTi, NCR− ILCs, and NCR+ ILC3s. +/− denotes cytokine expression by a subset of ILCs after activation for example with phorbol 12-myristate 13-acetate (PMA)/ionomycin.
GM-CSF, granulocyte-macrophage colony-stimulating factor.