Haploidentical stem cell transplantation (SCT): potential applications.
| Hematologic Malignancy . | Non-Malignant Stem Cell Disorders . | Tolerance Induction . |
|---|---|---|
| Abbreviations: DLI, donor lymphocyte infusion; GVT, graft-versus-tumor; SAA, severe aplastic anemia; SCID, severe combined immune deficiency. | ||
| Immediate availability of donor → Expansion of transplant opportunities | Available (often parent) donors for children with inherited stem cell disorders (e.g., SCID) | Avoidance of long term immunosuppression |
| Availability of donor for subsequent stems cell or DLI Potentially stronger GVT effect | Alternative donor source for acquired stem cell disorders (e.g., SAA) | Potential opportunities for cadaveric donor organ transplantation |
| Hematologic Malignancy . | Non-Malignant Stem Cell Disorders . | Tolerance Induction . |
|---|---|---|
| Abbreviations: DLI, donor lymphocyte infusion; GVT, graft-versus-tumor; SAA, severe aplastic anemia; SCID, severe combined immune deficiency. | ||
| Immediate availability of donor → Expansion of transplant opportunities | Available (often parent) donors for children with inherited stem cell disorders (e.g., SCID) | Avoidance of long term immunosuppression |
| Availability of donor for subsequent stems cell or DLI Potentially stronger GVT effect | Alternative donor source for acquired stem cell disorders (e.g., SAA) | Potential opportunities for cadaveric donor organ transplantation |