Anatomic localization of MALT lymphomas, cytogenetic alterations, deregulated genes and infectious etiologies.
| Anatomic Site . | Infectious Agent . | Translocation . | Gene . | Frequency . |
|---|---|---|---|---|
| * Frequency data based on references 25 & 26. | ||||
| ** Data supporting a definitive role for these organisms is lacking. | ||||
| Stomach | Helicobacter pylori | t(11;18)(q21;q21) t(1;14)(p22;q32) | API2-MALT1 fusion BCL10 | 22% 3% |
| Lung | ?? | t(11;18)(q21;q21) t(1;14)(p22;q32) | API2-MALT1 fusion BCL10 | 42% 7% |
| Intestine | Campylobacter jejuni** | t(11;18)(q21;q21) t(1;14)(p22;q32) | API2-MALT1 fusion BCL10 | 15% 10% |
| Ocular adnexa | Chlamydia psittaci** | t(3;14)(p14.1;q32) t(14;18)(q32;q21) | FOXP1 MALT1 | 20% 13% |
| Skin | Borrelia burgdorferi** | t(14;18)(q32;q21) t(3;14)(p14.1;q32) | MALT1 FOXP1 | 14% 10% |
| Salivary gland | Autoimmune? | t(14;18)(q32;p21) | MALT1 | 5% |
| Thyroid | Autoimmune? | t(3:14)(p14.1;q32) | FOXP1 | 50% |
| Anatomic Site . | Infectious Agent . | Translocation . | Gene . | Frequency . |
|---|---|---|---|---|
| * Frequency data based on references 25 & 26. | ||||
| ** Data supporting a definitive role for these organisms is lacking. | ||||
| Stomach | Helicobacter pylori | t(11;18)(q21;q21) t(1;14)(p22;q32) | API2-MALT1 fusion BCL10 | 22% 3% |
| Lung | ?? | t(11;18)(q21;q21) t(1;14)(p22;q32) | API2-MALT1 fusion BCL10 | 42% 7% |
| Intestine | Campylobacter jejuni** | t(11;18)(q21;q21) t(1;14)(p22;q32) | API2-MALT1 fusion BCL10 | 15% 10% |
| Ocular adnexa | Chlamydia psittaci** | t(3;14)(p14.1;q32) t(14;18)(q32;q21) | FOXP1 MALT1 | 20% 13% |
| Skin | Borrelia burgdorferi** | t(14;18)(q32;q21) t(3;14)(p14.1;q32) | MALT1 FOXP1 | 14% 10% |
| Salivary gland | Autoimmune? | t(14;18)(q32;p21) | MALT1 | 5% |
| Thyroid | Autoimmune? | t(3:14)(p14.1;q32) | FOXP1 | 50% |