Karyotypic abnormalities in small B-cell lymphomas.
| Disease Entity . | Cytogenetics . | Deregulated Genes . | Frequency (%) . |
|---|---|---|---|
| Abbreviations: SLL, small lymphocytic lymphoma; CLL, chronic lymphocytic leukemia; LPL, lymphoplasmacytic lymphoma; NMZL, nodal marginal zone lymphoma; SMZL, splenic marginal zone lymphoma; MCL, mantle cell lymphoma | |||
| SLL/CLL | +12, del11q, +13, −17p, rare t(14;19) | ?? BCL3 | 75 |
| LPL | Del6q | ?? | 30–70 |
| FL1-3A | t(14;18), t(3;14) or variants | BCL2, BCL6 | 95 |
| MALT | t(11;18), t(14;18), t(1;14), t(3;14), rare BCL6 translocations | API2-MALT1, MALT1, BCL10, FOXP1, BCL6 | Varies with anatomic site |
| NMZL | +3, +7, +18 | ?? | 50 |
| SMZL | Del7q31-32, del7q21 | ??, CDK6 | 70 |
| MCL | t(11;14) | Cyclin D1 | 96 |
| Disease Entity . | Cytogenetics . | Deregulated Genes . | Frequency (%) . |
|---|---|---|---|
| Abbreviations: SLL, small lymphocytic lymphoma; CLL, chronic lymphocytic leukemia; LPL, lymphoplasmacytic lymphoma; NMZL, nodal marginal zone lymphoma; SMZL, splenic marginal zone lymphoma; MCL, mantle cell lymphoma | |||
| SLL/CLL | +12, del11q, +13, −17p, rare t(14;19) | ?? BCL3 | 75 |
| LPL | Del6q | ?? | 30–70 |
| FL1-3A | t(14;18), t(3;14) or variants | BCL2, BCL6 | 95 |
| MALT | t(11;18), t(14;18), t(1;14), t(3;14), rare BCL6 translocations | API2-MALT1, MALT1, BCL10, FOXP1, BCL6 | Varies with anatomic site |
| NMZL | +3, +7, +18 | ?? | 50 |
| SMZL | Del7q31-32, del7q21 | ??, CDK6 | 70 |
| MCL | t(11;14) | Cyclin D1 | 96 |