Criteria for the diagnosis of POEMS syndrome.* (This research was originally published in Blood. Dispenzieri et al. POEMS syndrome: definitions and long-term outcome. Blood. 2003;101:2496–2506. © the American Society of Hematology)
| Abbreviations: POEMS, polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes. | |
| *Two major criteria and at least 1 minor criterion required for diagnosis. | |
| †Osteosclerotic lesion or Castleman disease is almost always present. | |
| ‡Because of the high prevalence of diabetes mellitus and thyroid abnormalities, this diagnosis alone is not sufficient to meet this minor criterion. | |
| Major criteria | Polyneuropathy Monoclonal plasma cell-proliferative disorder |
| Minor criteria | Sclerotic bone lesions† Castleman disease† Organomegaly (splenomegaly, hepatome galy, or lymphadenopathy) Edema (edema, pleural effusion, or ascites) Endocrinopathy (adrenal, thyroid,‡ pituitary, gonadal, parathyroid, pancreatic‡) Skin changes (hyperpigmentation, hypertri chosis, plethora, hemangiomata, white nails) Papilledema |
| Known associations | Clubbing Weight loss Thrombocytosis Polycythemia Hyperhidrosis |
| Possible associations | Pulmonary hypertension Restrictive lung disease Thrombotic diatheses Arthralgias Cardiomyopathy (systolic dysfunction) Fever Low vitamin B12 values Diarrhea |
| Abbreviations: POEMS, polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes. | |
| *Two major criteria and at least 1 minor criterion required for diagnosis. | |
| †Osteosclerotic lesion or Castleman disease is almost always present. | |
| ‡Because of the high prevalence of diabetes mellitus and thyroid abnormalities, this diagnosis alone is not sufficient to meet this minor criterion. | |
| Major criteria | Polyneuropathy Monoclonal plasma cell-proliferative disorder |
| Minor criteria | Sclerotic bone lesions† Castleman disease† Organomegaly (splenomegaly, hepatome galy, or lymphadenopathy) Edema (edema, pleural effusion, or ascites) Endocrinopathy (adrenal, thyroid,‡ pituitary, gonadal, parathyroid, pancreatic‡) Skin changes (hyperpigmentation, hypertri chosis, plethora, hemangiomata, white nails) Papilledema |
| Known associations | Clubbing Weight loss Thrombocytosis Polycythemia Hyperhidrosis |
| Possible associations | Pulmonary hypertension Restrictive lung disease Thrombotic diatheses Arthralgias Cardiomyopathy (systolic dysfunction) Fever Low vitamin B12 values Diarrhea |