Table 2.

Clinical features POEMS patients—three series.

Mayo Series3 French Series1 Japanese Series2 
%n=99%n=25%n=102
Abbreviations: NS, not stated 
Comment: The percentage for all series uses the total number of patients in the series as the denominator 
*Includes gonadal and adrenal abnormalities 
**Of patients with bone lesions 
This table was modified froma table originally published in Blood. Dispenzieri et al. POEMS syndrome: definitions and long-term outcome.
Blood
.
2003
;
101
:
2496
–2506
. © by the American Society of Hematology. 
Peripheral neuropathy 100 100 100 
Organomegaly 46 NS NS 
    Hepatomegaly 25 68 78 
    Splenomegaly 22 52 35 
    Lymphadenopathy 26 52 61 
Endocrinopathy 71* NS NS 
    Diabetes 3 36 25 
    Hypothyroidism 17 36  
Monoclonal plasma cell dyscrasia 100 100 75 
Skin Changes 68 NS NS 
    Hyperpigmentation 46 48 93 
    Acrocyanosis and plethora 19 NS NS 
    Hemangioma/telangectasia 9 32 NS 
    Hypertrichosis 26 24 74 
    Thickening 5 28 61 
Sclerotic bone lesions 97 68 54 
    Osteosclerotic only** 47 41 56 
    Mixed sclerotic and lytic** 51 59 31 
    Lytic only** 2 0 13 
    > 1 lesion** 54 59 45 
Papilledema 29 40 55 
Extravascular volume overload 39 NS NS 
    Peripheral edema 29 80 89 
    Ascites 15 32 52 
    Pleural effusion 9 24 35 
Castleman disease 11 24 19 
Other features 
    Thrombocytosis 54 88 NS 
    Polycythemia 18 12 19 
    Clubbing 5 32 49 
Mayo Series3 French Series1 Japanese Series2 
%n=99%n=25%n=102
Abbreviations: NS, not stated 
Comment: The percentage for all series uses the total number of patients in the series as the denominator 
*Includes gonadal and adrenal abnormalities 
**Of patients with bone lesions 
This table was modified froma table originally published in Blood. Dispenzieri et al. POEMS syndrome: definitions and long-term outcome.
Blood
.
2003
;
101
:
2496
–2506
. © by the American Society of Hematology. 
Peripheral neuropathy 100 100 100 
Organomegaly 46 NS NS 
    Hepatomegaly 25 68 78 
    Splenomegaly 22 52 35 
    Lymphadenopathy 26 52 61 
Endocrinopathy 71* NS NS 
    Diabetes 3 36 25 
    Hypothyroidism 17 36  
Monoclonal plasma cell dyscrasia 100 100 75 
Skin Changes 68 NS NS 
    Hyperpigmentation 46 48 93 
    Acrocyanosis and plethora 19 NS NS 
    Hemangioma/telangectasia 9 32 NS 
    Hypertrichosis 26 24 74 
    Thickening 5 28 61 
Sclerotic bone lesions 97 68 54 
    Osteosclerotic only** 47 41 56 
    Mixed sclerotic and lytic** 51 59 31 
    Lytic only** 2 0 13 
    > 1 lesion** 54 59 45 
Papilledema 29 40 55 
Extravascular volume overload 39 NS NS 
    Peripheral edema 29 80 89 
    Ascites 15 32 52 
    Pleural effusion 9 24 35 
Castleman disease 11 24 19 
Other features 
    Thrombocytosis 54 88 NS 
    Polycythemia 18 12 19 
    Clubbing 5 32 49 
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