Number of cases of drug-induced immune hemolytic anemia (DIIHA) encountered by us over a 40-year period (10 years in San Francisco and 30 years in Southern California).
| . | . | Southern California (Garratty, Arndt, and Leger) . | |||
|---|---|---|---|---|---|
| Drug* . | San Francisco (Garratty and Petz) 1969–1978 (10 yrs) . | 1979–1988 (10 yrs) . | 1989–1998 (10 yrs) . | 1999–2008 (10 yrs) . | 1979–2008 (30 yrs) . |
| *Columns contain number (percentage) of cases associated with each drug | |||||
| **Quinine (2), hydrochlorothiazide, rifampin | |||||
| †Probenicid (2), chlorpropamide, phenacetin, nafcillin, rifampin, procainamide, erythromycin | |||||
| ‡Fludarabine (2), probenecid, tolectin, mefloquine, ticarcillin | |||||
| §Oxaliplatin (2), carboplatin, rifampin, diclofenac, cimetidine, trimethoprim, sulfamethoxazole | |||||
| Methyldopa | 29 (67%) | 0 | 0 | 0 | 0 (0%) |
| Penicillin | 10 (23%) | 2 (15%) | 0 | 0 | 2 (1.3%) |
| Cefotetan | 0 | 0 | 36 (69%) | 45 (53%) | 81 (54%) |
| Ceftriaxone | 0 | 1 (8%) | 5 (10%) | 14 (17%) | 20 (13%) |
| Other cephalosporins | 0 | 2 (15%) | 0 | 0 | 2 (1.3%) |
| β-lactamase inhibitors | 0 | 0 | 4 (8%) | 6 (7%) | 10 (7%) |
| Piperacillin | 0 | 0 | 1 (2%) | 12 (14%) | 13 (9%) |
| Others | 4** (9.3%) | 8† (62%) | 6‡ (12%) | 8§ (9%) | 22 (15%) |
| TOTAL | 43 | 13 | 52 | 85 | 150 |
| . | . | Southern California (Garratty, Arndt, and Leger) . | |||
|---|---|---|---|---|---|
| Drug* . | San Francisco (Garratty and Petz) 1969–1978 (10 yrs) . | 1979–1988 (10 yrs) . | 1989–1998 (10 yrs) . | 1999–2008 (10 yrs) . | 1979–2008 (30 yrs) . |
| *Columns contain number (percentage) of cases associated with each drug | |||||
| **Quinine (2), hydrochlorothiazide, rifampin | |||||
| †Probenicid (2), chlorpropamide, phenacetin, nafcillin, rifampin, procainamide, erythromycin | |||||
| ‡Fludarabine (2), probenecid, tolectin, mefloquine, ticarcillin | |||||
| §Oxaliplatin (2), carboplatin, rifampin, diclofenac, cimetidine, trimethoprim, sulfamethoxazole | |||||
| Methyldopa | 29 (67%) | 0 | 0 | 0 | 0 (0%) |
| Penicillin | 10 (23%) | 2 (15%) | 0 | 0 | 2 (1.3%) |
| Cefotetan | 0 | 0 | 36 (69%) | 45 (53%) | 81 (54%) |
| Ceftriaxone | 0 | 1 (8%) | 5 (10%) | 14 (17%) | 20 (13%) |
| Other cephalosporins | 0 | 2 (15%) | 0 | 0 | 2 (1.3%) |
| β-lactamase inhibitors | 0 | 0 | 4 (8%) | 6 (7%) | 10 (7%) |
| Piperacillin | 0 | 0 | 1 (2%) | 12 (14%) | 13 (9%) |
| Others | 4** (9.3%) | 8† (62%) | 6‡ (12%) | 8§ (9%) | 22 (15%) |
| TOTAL | 43 | 13 | 52 | 85 | 150 |