Recommended liver iron concentrations (LIC) for the treatment of transfused thalassemia patients.18 Conversion factors19 are related to in vivo LIC and are additionally calculated for LIC from paraffin embedded biopsies (paraffin block PB). The widely adopted wet-to-dry weight factor of 3.3318 is based on the water content of 70% of normal autopsy liver.
| LIC (in vivo) (mg/gliver wet weight) . | LIC (70% water) (mg/gdry w.) . | LIC (PB) (mg/gdry w.) . | Comment . |
|---|---|---|---|
| 3.33 | 5.83 | Conversion factor | |
| 1.005 | 3.3 | 5.9 ± 1.0 | Lower optimal threshold18 |
| 2.122 | 7.0 | 12.4 ± 2.1 | Upper optimal threshold18 |
| 4.468 | 15.0 | 26.0 ± 4.5 | High risk of cardiac disease18 |
| LIC (in vivo) (mg/gliver wet weight) . | LIC (70% water) (mg/gdry w.) . | LIC (PB) (mg/gdry w.) . | Comment . |
|---|---|---|---|
| 3.33 | 5.83 | Conversion factor | |
| 1.005 | 3.3 | 5.9 ± 1.0 | Lower optimal threshold18 |
| 2.122 | 7.0 | 12.4 ± 2.1 | Upper optimal threshold18 |
| 4.468 | 15.0 | 26.0 ± 4.5 | High risk of cardiac disease18 |