Medical conditions and complications of pregnancy and delivery associated with an increased risk of venous throembolism in pregnancy.
| . | Lindqqvist et al12 . | Danilenko-Dixon et al23 . | Simpson et al13 . | James et al5 . | Larsen et al34 . | Jacobsen et al14 . |
|---|---|---|---|---|---|---|
| . | . | Odds ratios and 95% confidence intervals . | ||||
| Patient Characteristics | ||||||
| Age > 35 | 1.3 (1.0, 1.7) | – | 1.5 (1.1, 2.2) | 1.4 (1.2, 1.8) | – | – |
| Nulliparity | 1.8 (1.2, 2.7) | 0.9 (0.37, 2.2) | – | – | – | 1.7 (1.3, 2.3) antenatal |
| Para 2 | 1.5 (1.1, 1.9) | – | – | – | – | 0.8 (0.5, 1.2) antenatal |
| Para ≥ 2 | – | – | – | – | – | – |
| Para ≥ 3 | 2.4 (1.8, 3.1) | – | – | – | – | 1.9 (1.2, 3.0) postnatal |
| African-American race | – | – | – | 1.4 (1.2, 1.6) | – | |
| Medical Conditions | ||||||
| Heart disease | – | – | 5.1 (2.5, 10.5) | 7.1 (6.2, 8.3) | – | – |
| Sickle cell disease | – | – | – | 6.7 (4.4, 10.1) | – | – |
| Systemic lupus erythematosus | – | – | – | 8.7 (5.8, 13.0) | – | – |
| Obesity | – | – | – | 4.4 (3.4, 5.7) | 5.3 (2.1, 13.5) BMI >30 | – |
| Diabetes | – | – | – | 2.0 (1.4, 2.7) | – | – |
| Hypertension | – | – | – | 1.8 (1.4, 2.3) | – | – |
| History of superficial thrombophlebitis | – | 10.0 (1.3, 78) | – | – | – | – |
| Smoking | 1.4 (1.1, 1.9) for ≥ 10 per day | 2.5 (1.3, 4.7) | – | 1.7 (1.4, 2.1) | 2.7 (1.5, 4.9) | – |
| Complications of Pregnancy and Delivery | ||||||
| Assisted reproduction | – | – | – | – | – | 4.4 (2.6, 7.5) antenatal |
| Multiple gestation | 1.8 (1.1, 3.0) | 7.0 (0.36, 135) | – | 1.6 (1.2, 2.1) | – | 2.7 (1.6, 4.5) antenatal |
| Hyperemesis | – | – | – | 2.5 (2.0, 3.2) | – | – |
| Gestational diabetes | – | – | – | – | – | 4.0 (2.0, 8.9) antenatal |
| Antepartum hemorrhage | – | – | – | 2.3 (1.8, 2.8) | – | – |
| Preeclampsia | 2.9 (2.1, 3.9) | 1.0 (0.15, 7.1) | – | 0.9 (0.7, 1.0) | – | 3.8 (2.8, 5.1) postnatal |
| Cesarean delivery | 3.6 (3.0, 4.3) | 1.2 (0.9, 1.5) | 2.6 (1.9, 3.4) | 2.1 (1.8, 2.4) | 2.7 (1.8, 4.0) planned 4.0 (3.0, 5.3) emergency | |
| Postpartum infection | – | – | – | 4.1 (2.9, 5.7) | – | – |
| Postpartum hemorrhage | – | 9.0 (1.1, 71) | – | 1.3 (1.1, 1.6) | – | – |
| Transfusion | – | 5.0 (0.58, 43) | – | 7.6 (6.2, 9.4) | – | – |
| . | Lindqqvist et al12 . | Danilenko-Dixon et al23 . | Simpson et al13 . | James et al5 . | Larsen et al34 . | Jacobsen et al14 . |
|---|---|---|---|---|---|---|
| . | . | Odds ratios and 95% confidence intervals . | ||||
| Patient Characteristics | ||||||
| Age > 35 | 1.3 (1.0, 1.7) | – | 1.5 (1.1, 2.2) | 1.4 (1.2, 1.8) | – | – |
| Nulliparity | 1.8 (1.2, 2.7) | 0.9 (0.37, 2.2) | – | – | – | 1.7 (1.3, 2.3) antenatal |
| Para 2 | 1.5 (1.1, 1.9) | – | – | – | – | 0.8 (0.5, 1.2) antenatal |
| Para ≥ 2 | – | – | – | – | – | – |
| Para ≥ 3 | 2.4 (1.8, 3.1) | – | – | – | – | 1.9 (1.2, 3.0) postnatal |
| African-American race | – | – | – | 1.4 (1.2, 1.6) | – | |
| Medical Conditions | ||||||
| Heart disease | – | – | 5.1 (2.5, 10.5) | 7.1 (6.2, 8.3) | – | – |
| Sickle cell disease | – | – | – | 6.7 (4.4, 10.1) | – | – |
| Systemic lupus erythematosus | – | – | – | 8.7 (5.8, 13.0) | – | – |
| Obesity | – | – | – | 4.4 (3.4, 5.7) | 5.3 (2.1, 13.5) BMI >30 | – |
| Diabetes | – | – | – | 2.0 (1.4, 2.7) | – | – |
| Hypertension | – | – | – | 1.8 (1.4, 2.3) | – | – |
| History of superficial thrombophlebitis | – | 10.0 (1.3, 78) | – | – | – | – |
| Smoking | 1.4 (1.1, 1.9) for ≥ 10 per day | 2.5 (1.3, 4.7) | – | 1.7 (1.4, 2.1) | 2.7 (1.5, 4.9) | – |
| Complications of Pregnancy and Delivery | ||||||
| Assisted reproduction | – | – | – | – | – | 4.4 (2.6, 7.5) antenatal |
| Multiple gestation | 1.8 (1.1, 3.0) | 7.0 (0.36, 135) | – | 1.6 (1.2, 2.1) | – | 2.7 (1.6, 4.5) antenatal |
| Hyperemesis | – | – | – | 2.5 (2.0, 3.2) | – | – |
| Gestational diabetes | – | – | – | – | – | 4.0 (2.0, 8.9) antenatal |
| Antepartum hemorrhage | – | – | – | 2.3 (1.8, 2.8) | – | – |
| Preeclampsia | 2.9 (2.1, 3.9) | 1.0 (0.15, 7.1) | – | 0.9 (0.7, 1.0) | – | 3.8 (2.8, 5.1) postnatal |
| Cesarean delivery | 3.6 (3.0, 4.3) | 1.2 (0.9, 1.5) | 2.6 (1.9, 3.4) | 2.1 (1.8, 2.4) | 2.7 (1.8, 4.0) planned 4.0 (3.0, 5.3) emergency | |
| Postpartum infection | – | – | – | 4.1 (2.9, 5.7) | – | – |
| Postpartum hemorrhage | – | 9.0 (1.1, 71) | – | 1.3 (1.1, 1.6) | – | – |
| Transfusion | – | 5.0 (0.58, 43) | – | 7.6 (6.2, 9.4) | – | – |