Protocols for thromboprophylaxis in pregnancy.40,55
| . | Bates et al 200840 . | Duke Protocol55 . |
|---|---|---|
| Unfractionated heparin | ||
| Mini-dose | ▪ 5000 U sc q 12 hrs | ▪ 5000 U sc q 12 hrs < 8 weeks |
| “low dose” | ▪ 7500 U sc q 12 hrs 8–28 weeks | |
| “prophylactic dose” | ▪ 10,000 U sc q 12 hrs > 28 weeks | |
| Intermediate (moderate) dose | ▪ q 12 hrs to target anti-factor Xa level of 0.1–0.3 U/mL | |
| “low dose” | ||
| Adjusted dose | ▪ q12 hrs to target mid-interval aPTT in therapeutic range | ▪ q 8 or12 hrs to target mid-interval aPTT in therapeutic range |
| “full dose” | ||
| Low-molecular-weight heparin | ||
| Prophylactic dose or | ▪ Enoxaparin 40 mg qd | ▪ Enoxaparin 40 mg qd or 30 mg bid before 28 weeks then |
| “low dose” | ▪ Dalteparin 5000 U qd | ▪ Enoxaparin 40 mg bid after 28 weeks |
| ▪ Tinzaparin 4500 U qd | ||
| Intermediate or moderate dose | ▪ Dalteparin 5000 U q 12 hrs or | |
| ▪ Enoxaparin 40 mg q 12 hrs | ||
| Weight-adjusted dose | ▪ Enoxaparin 1 mg/kg bid | ▪ Enoxaparin 1 mg/kg bid with target of anti-factor Xa level of 0.5–1.0 with monthly levels |
| “full dose” | ▪ Dalteparin 100 U/kg q 12 hrs or 200 U/kg q 24 hrs | |
| ▪ Tinzaparin 175 mg U/kg qd | ||
| . | Bates et al 200840 . | Duke Protocol55 . |
|---|---|---|
| Unfractionated heparin | ||
| Mini-dose | ▪ 5000 U sc q 12 hrs | ▪ 5000 U sc q 12 hrs < 8 weeks |
| “low dose” | ▪ 7500 U sc q 12 hrs 8–28 weeks | |
| “prophylactic dose” | ▪ 10,000 U sc q 12 hrs > 28 weeks | |
| Intermediate (moderate) dose | ▪ q 12 hrs to target anti-factor Xa level of 0.1–0.3 U/mL | |
| “low dose” | ||
| Adjusted dose | ▪ q12 hrs to target mid-interval aPTT in therapeutic range | ▪ q 8 or12 hrs to target mid-interval aPTT in therapeutic range |
| “full dose” | ||
| Low-molecular-weight heparin | ||
| Prophylactic dose or | ▪ Enoxaparin 40 mg qd | ▪ Enoxaparin 40 mg qd or 30 mg bid before 28 weeks then |
| “low dose” | ▪ Dalteparin 5000 U qd | ▪ Enoxaparin 40 mg bid after 28 weeks |
| ▪ Tinzaparin 4500 U qd | ||
| Intermediate or moderate dose | ▪ Dalteparin 5000 U q 12 hrs or | |
| ▪ Enoxaparin 40 mg q 12 hrs | ||
| Weight-adjusted dose | ▪ Enoxaparin 1 mg/kg bid | ▪ Enoxaparin 1 mg/kg bid with target of anti-factor Xa level of 0.5–1.0 with monthly levels |
| “full dose” | ▪ Dalteparin 100 U/kg q 12 hrs or 200 U/kg q 24 hrs | |
| ▪ Tinzaparin 175 mg U/kg qd | ||