▪ Patient bleeding, thrombosing, or both, typically with progressive organ dysfunction.

▪ An underlying illness or process that may cause tissue damage, cell death, or production/release of tissue factor (TF).

▪ Usually some perturbation exists of simple, readily available tests such as thrombin time (TT), prothrombin time (PT), partial thromboplastin time (PTT), fibrin degradation products (FDP), D-dimer, or platelet count. These values may markedly change as the clinical situation changes.