Evidence for and against asthma as a distinct co-morbid disease in individuals with sickle cell disease (SCD).
| Pros . | References . | Cons . | References . |
|---|---|---|---|
| Similar prevalence of asthma in the general population and in children with SCD | 4–6 | Higher prevalence of airway hyper-responsiveness in individuals with SCD when compared with the general population | 52–56 |
| Familial pattern of asthma inheritance among children with SCD | 51 | Higher prevalence of airway obstruction in children with SCD when compared with the general population | 57 |
| Overlap of symptoms between acute chest syndrome and asthma | 13 |
| Pros . | References . | Cons . | References . |
|---|---|---|---|
| Similar prevalence of asthma in the general population and in children with SCD | 4–6 | Higher prevalence of airway hyper-responsiveness in individuals with SCD when compared with the general population | 52–56 |
| Familial pattern of asthma inheritance among children with SCD | 51 | Higher prevalence of airway obstruction in children with SCD when compared with the general population | 57 |
| Overlap of symptoms between acute chest syndrome and asthma | 13 |