Table 1. Results of different randomized... | American Society of Hematology

Table 1.

Results of different randomized studies comparing chemotherapy to rituximab plus chemotherapy in previously untreated patients with diffuse large B-cell lymphoma (DLBCL).

Trial, Median follow-up, Treatment	Study characteristics	EFS or FFS, %	Pvalue	OS, %	Pvalue
Abbreviations: CR, complete remission; EFS, event-free survival; FFS, failure-free survival; OS, overall survival; NS, not significant; NA, not available
*secondary analysis; ^†both rituximab arms only; ^‡for 6×R-CHOP-14 versus 6×CHOP-14
GELA¹⁰	DLBCL	EFS	< .0001		.0004
7 years	60–80 y
R-CHOP	All IPI	42		53
CHOP	Intent-to-treat analysis	25		36
US Intergroup
(ECOG/	DLBCL
CALGB) study¹¹	Age >60 y
3 years	All IPI	FFS
R-CHOP*	Intent-to-treat analysis	52	.003	67	.05
CHOP		39		58
2 years*
R-CHOP		77	< .001	NA	NA
R-CHOP + MR		79
CHOP + MR		74
CHOP		45
MinT¹⁴		EFS
3 years
	DLBCL
R-chemotherapy	age < 60 y	79 ±	< .0001	93	.0001
chemotherapy	IPI score 0–1	59		84
	Intent to treat analysis
RICOVER¹⁹		EFS
3 years
6×CHOP-14	DLBCL	47	< .001^†	68	.003^‡
8×CHOP-14	Age 61–80 y	52		66
6×R-CHOP-14	All IPI	66		78
8×R-CHOP-14		63		72

Trial, Median follow-up, Treatment	Study characteristics	EFS or FFS, %	Pvalue	OS, %	Pvalue
Abbreviations: CR, complete remission; EFS, event-free survival; FFS, failure-free survival; OS, overall survival; NS, not significant; NA, not available
*secondary analysis; ^†both rituximab arms only; ^‡for 6×R-CHOP-14 versus 6×CHOP-14
GELA¹⁰	DLBCL	EFS	< .0001		.0004
7 years	60–80 y
R-CHOP	All IPI	42		53
CHOP	Intent-to-treat analysis	25		36
US Intergroup
(ECOG/	DLBCL
CALGB) study¹¹	Age >60 y
3 years	All IPI	FFS
R-CHOP*	Intent-to-treat analysis	52	.003	67	.05
CHOP		39		58
2 years*
R-CHOP		77	< .001	NA	NA
R-CHOP + MR		79
CHOP + MR		74
CHOP		45
MinT¹⁴		EFS
3 years
	DLBCL
R-chemotherapy	age < 60 y	79 ±	< .0001	93	.0001
chemotherapy	IPI score 0–1	59		84
	Intent to treat analysis
RICOVER¹⁹		EFS
3 years
6×CHOP-14	DLBCL	47	< .001^†	68	.003^‡
8×CHOP-14	Age 61–80 y	52		66
6×R-CHOP-14	All IPI	66		78
8×R-CHOP-14		63		72

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