Major recurring genetic events in diffuse large B-cell lymphoma (DLBCL).
| Genetic Defect . | Frequency, % . | Location . | Mechanism of deregulation . |
|---|---|---|---|
| Abbreviations: SHM, somatic hypermutation | |||
| Reprinted with permission from Abramson and Shipp.2 | |||
| BCL6 | 35–40 | 3q27 | t(3;…) and SHM |
| BCL2 | t(14;18): 13 amplification: 24 | 18q21 | t(14;18) and gene amplification |
| cMYC | 15 | 8q24 | t(8;…) and SHM |
| FAS(CD95) | 20 | 10q24 | Death domain mutations, ?SHM |
| SHM | 45 | Physiologic: Ig(v), FAS, BCL6 Aberrant: BCL6, PIM1, cMYC, PAX5, RhoH/TTF, ?FAS | SHM |
| p53 | 16 | 17p | Mutation, deletion |
| Genetic Defect . | Frequency, % . | Location . | Mechanism of deregulation . |
|---|---|---|---|
| Abbreviations: SHM, somatic hypermutation | |||
| Reprinted with permission from Abramson and Shipp.2 | |||
| BCL6 | 35–40 | 3q27 | t(3;…) and SHM |
| BCL2 | t(14;18): 13 amplification: 24 | 18q21 | t(14;18) and gene amplification |
| cMYC | 15 | 8q24 | t(8;…) and SHM |
| FAS(CD95) | 20 | 10q24 | Death domain mutations, ?SHM |
| SHM | 45 | Physiologic: Ig(v), FAS, BCL6 Aberrant: BCL6, PIM1, cMYC, PAX5, RhoH/TTF, ?FAS | SHM |
| p53 | 16 | 17p | Mutation, deletion |