Secondary analyses of the Multi-center Study of Hydroxyurea (MSH) trial and the Stroke Prevention (STOP) trial.
| Secondary analysis . | Title . | Level of significance . |
|---|---|---|
| MSH | ||
| Ballas et al36 (2006) | Hydroxyurea and sickle cell anemia: effect on quality of life | .01 |
| Steinberg et al37 (2003) | Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment | .05 |
| Moore et al38 (2000) | Cost-effectiveness of hydroxyurea in sickle cell anemia | .05 |
| Steinberg et al39 (1997) | Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea | .01 |
| STOP | ||
| Kwiatkowski et al40 (2006) | Elevated blood flow velocity in the anterior cerebral artery and stroke risk in sickle cell disease: extended analysis from the STOP trial | .05 |
| Lee et al41 (2006) | STOP: extended follow-up and final results | Not stated |
| Lezcano et al42 (2006) | Regular transfusion lowers plasma free hemoglobin in children with sickle cell disease at risk for stroke | .05 |
| Wang et al43 (2005) | Effect of long-term transfusion on growth in children with sickle cell anemia: results of the STOP trial | .05 |
| Abboud et al44 (2004) | Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial doppler ultrasonography findings enrolled in the STOP study | .05 |
| Adams et al45 (2004) | Stroke and conversion to high risk in children screened with transcranial doppler ultrasound during the STOP study | Not stated |
| Jones et al46 (2004) | Can peak systolic velocities be used for prediction of stroke in sickle cell anemia? | Not stated |
| Hsu et al47 (2003) | Alpha thalassemia is associated with decreased risk of abnormal transcranial doppler ultrasonography in children with sickle cell anemia | .05 |
| Files et al48(2002) | Longitudinal changes in ferritin during chronic transfusion: a report from the STOP trial | Not stated |
| Miller et al49 (2001) | Impact of chronic transfusion on incidence of pain and acute chest syndrome during the STOP trial in sickle cell anemia | .05 |
| Wang et al50 (2000) | Multicenter comparison of magnetic resonance imaging and transcranial doppler ultrasonography in the evaluation of the central nervous system in children with sickle cell disease | Not stated |
| Secondary analysis . | Title . | Level of significance . |
|---|---|---|
| MSH | ||
| Ballas et al36 (2006) | Hydroxyurea and sickle cell anemia: effect on quality of life | .01 |
| Steinberg et al37 (2003) | Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment | .05 |
| Moore et al38 (2000) | Cost-effectiveness of hydroxyurea in sickle cell anemia | .05 |
| Steinberg et al39 (1997) | Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea | .01 |
| STOP | ||
| Kwiatkowski et al40 (2006) | Elevated blood flow velocity in the anterior cerebral artery and stroke risk in sickle cell disease: extended analysis from the STOP trial | .05 |
| Lee et al41 (2006) | STOP: extended follow-up and final results | Not stated |
| Lezcano et al42 (2006) | Regular transfusion lowers plasma free hemoglobin in children with sickle cell disease at risk for stroke | .05 |
| Wang et al43 (2005) | Effect of long-term transfusion on growth in children with sickle cell anemia: results of the STOP trial | .05 |
| Abboud et al44 (2004) | Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial doppler ultrasonography findings enrolled in the STOP study | .05 |
| Adams et al45 (2004) | Stroke and conversion to high risk in children screened with transcranial doppler ultrasound during the STOP study | Not stated |
| Jones et al46 (2004) | Can peak systolic velocities be used for prediction of stroke in sickle cell anemia? | Not stated |
| Hsu et al47 (2003) | Alpha thalassemia is associated with decreased risk of abnormal transcranial doppler ultrasonography in children with sickle cell anemia | .05 |
| Files et al48(2002) | Longitudinal changes in ferritin during chronic transfusion: a report from the STOP trial | Not stated |
| Miller et al49 (2001) | Impact of chronic transfusion on incidence of pain and acute chest syndrome during the STOP trial in sickle cell anemia | .05 |
| Wang et al50 (2000) | Multicenter comparison of magnetic resonance imaging and transcranial doppler ultrasonography in the evaluation of the central nervous system in children with sickle cell disease | Not stated |