Differential diagnosis between thrombotic thrombocytopenic purpura (TTP) and other thrombotic microangiopathies.
| Disease . | Common symptoms . | Differential symptoms . |
|---|---|---|
| Hemolytic uremic syndrome | Thrombocytopenia, hemolytic anemia with schistocytosis | Gastrointestinal infections: E. coli 0157:H7, Shigella dysenteria Hemorrhagic colitis High serum creatinine |
| HELLP syndrome | Hemolytic anemia, thrombocytopenia | Elevated liver enzymes |
| Pre-eclampsia, eclampsia | Thrombocytopenia, proteinuria | Hypertension Peripheral edema Proteinuria Increased D-dimer |
| Disseminated intravascular coagulation | Thrombocytopenia | Markedly increased D-dimer Prolonged prothrombin time |
| Catastrophic antiphospholipid syndrome | Thrombocytopenia Positive lupus-like anticoagulant | Antinuclear and antiphospholipid antibodies |
| Evans syndrome | Hemolytic anemia, thrombocytopenia | Positive Coombs test Usually absence of end-organ ischemic symptoms |
| Heparin-induced thrombocytopenia | Thrombocytopenia | Thrombosis mainly in large arteries and veins Antiplatelet antibodies |
| Disease . | Common symptoms . | Differential symptoms . |
|---|---|---|
| Hemolytic uremic syndrome | Thrombocytopenia, hemolytic anemia with schistocytosis | Gastrointestinal infections: E. coli 0157:H7, Shigella dysenteria Hemorrhagic colitis High serum creatinine |
| HELLP syndrome | Hemolytic anemia, thrombocytopenia | Elevated liver enzymes |
| Pre-eclampsia, eclampsia | Thrombocytopenia, proteinuria | Hypertension Peripheral edema Proteinuria Increased D-dimer |
| Disseminated intravascular coagulation | Thrombocytopenia | Markedly increased D-dimer Prolonged prothrombin time |
| Catastrophic antiphospholipid syndrome | Thrombocytopenia Positive lupus-like anticoagulant | Antinuclear and antiphospholipid antibodies |
| Evans syndrome | Hemolytic anemia, thrombocytopenia | Positive Coombs test Usually absence of end-organ ischemic symptoms |
| Heparin-induced thrombocytopenia | Thrombocytopenia | Thrombosis mainly in large arteries and veins Antiplatelet antibodies |