Spectrum of tyrosine kinase inhibition for imatinib and novel compounds.
| Drug . | Kinases inhibited . |
|---|---|
| Imatinib | BCR-ABL, c-kit, PDGFR |
| Dasatinib | BCR-ABL, Src family kinases, c-kit, ephrin receptor kinases, PDGFR |
| Nilotinib | BCR-ABL, c-kit, PDGFR |
| Bosutinib | BCR-ABL, Src family kinases |
| MK-0547 | BCR-ABL, aurora kinases, JAK2, FLT3 |
| INNO-406 | BCR-ABL, Lyn kinase |
| BIRB-796 | BCR-ABL, p38 mitogen-activated protein (MAP) kinase |
| Drug . | Kinases inhibited . |
|---|---|
| Imatinib | BCR-ABL, c-kit, PDGFR |
| Dasatinib | BCR-ABL, Src family kinases, c-kit, ephrin receptor kinases, PDGFR |
| Nilotinib | BCR-ABL, c-kit, PDGFR |
| Bosutinib | BCR-ABL, Src family kinases |
| MK-0547 | BCR-ABL, aurora kinases, JAK2, FLT3 |
| INNO-406 | BCR-ABL, Lyn kinase |
| BIRB-796 | BCR-ABL, p38 mitogen-activated protein (MAP) kinase |