Classification schemes in chronic myeloid leukemia (CML), accelerated and blast phases.
| Features . | Sokol . | IBMT . | MDA . | WHO . |
|---|---|---|---|---|
| An abbreviated summary of different classification schemes for CML. The greatest variation is defining the transition from chronic phase to accelerated (top three rows). The differences in the definition of blast crisis focus on the percentage of blast counts in the bone marrow or peripheral blood. | ||||
| Definitions: “Blast %” refers to peripheral blood or bone marrow; “clonal evolution” are secondary chromosomal changes in addition to the Philadelphia chromosome (Ph); Platelet count refers to significant changes (e.g., > 1 × 1012/L) while on therapy. Abbreviations: IBMT, International Bone marrow Transplantation; MDA, MD Ander-son; WHO, World Health Organization. | ||||
| Blast % | ≥ 5 | ≥ 10 | ≥ 15 | 10-19 |
| Clonal evolution? | Yes | Yes | Yes | Yes |
| Platelet count | Increased | Decreased | Decreased | Increased/decreased |
| Blast count (BC), % | ≥ 30 | ≥ 30 | ≥ 30 | ≥ 20 |
| Features . | Sokol . | IBMT . | MDA . | WHO . |
|---|---|---|---|---|
| An abbreviated summary of different classification schemes for CML. The greatest variation is defining the transition from chronic phase to accelerated (top three rows). The differences in the definition of blast crisis focus on the percentage of blast counts in the bone marrow or peripheral blood. | ||||
| Definitions: “Blast %” refers to peripheral blood or bone marrow; “clonal evolution” are secondary chromosomal changes in addition to the Philadelphia chromosome (Ph); Platelet count refers to significant changes (e.g., > 1 × 1012/L) while on therapy. Abbreviations: IBMT, International Bone marrow Transplantation; MDA, MD Ander-son; WHO, World Health Organization. | ||||
| Blast % | ≥ 5 | ≥ 10 | ≥ 15 | 10-19 |
| Clonal evolution? | Yes | Yes | Yes | Yes |
| Platelet count | Increased | Decreased | Decreased | Increased/decreased |
| Blast count (BC), % | ≥ 30 | ≥ 30 | ≥ 30 | ≥ 20 |