Other clinical manifestations at initial diagnosis of chronic graft-versus-host disease (GVHD) and ever noted, based on 324 patients diagnosed with chronic GVHD according to NIH consensus criteria, transplanted at FHCRC 2003–2005.(M. Flowers, unpublished data)
| . | At onset, % . | Ever, % . |
|---|---|---|
| Sites involved | ||
| Skin | 74 | 81 |
| Finger/toenail/mouth | 8 | 19 |
| Mouth | 87 | 89 |
| Eyes | 34 | 47 |
| G.I. tract | 40 | 48 |
| Esophagus | 1 | 5 |
| Liver | 35 | 47 |
| Vagina/penis | 4 | 10 |
| Lungs | 3 | 14 |
| Joints | 7 | 15 |
| Muscle | 2 | 2 |
| Serosa | 2 | 2 |
| Myofascial | 6 | 16 |
| Clinical manifestations/complications | ||
| Weight loss | 22 | 31 |
| Joint contracture | 2 | 7 |
| Malabsorption | <1 | 1 |
| Keratoconjunctivitis | 3 | 8 |
| Cutaneous sclerosis | 4 | 13 |
| Esophageal stricture | <1 | 1 |
| Bronchiolitis obliterans syndrome | <1 | 7 |
| Eosinophilia | 14 | 20 |
| Bronchiolitis obliterans organizing pneumonia | 2 | 4 |
| Other characteristics | ||
| Progressive onset | 13 | |
| Quiescent onset | 60 | |
| De novo onset | 27 | |
| On steroids at diagnosis | 34 | |
| Platelets < 100,000 at diagnosis | 31 | |
| . | At onset, % . | Ever, % . |
|---|---|---|
| Sites involved | ||
| Skin | 74 | 81 |
| Finger/toenail/mouth | 8 | 19 |
| Mouth | 87 | 89 |
| Eyes | 34 | 47 |
| G.I. tract | 40 | 48 |
| Esophagus | 1 | 5 |
| Liver | 35 | 47 |
| Vagina/penis | 4 | 10 |
| Lungs | 3 | 14 |
| Joints | 7 | 15 |
| Muscle | 2 | 2 |
| Serosa | 2 | 2 |
| Myofascial | 6 | 16 |
| Clinical manifestations/complications | ||
| Weight loss | 22 | 31 |
| Joint contracture | 2 | 7 |
| Malabsorption | <1 | 1 |
| Keratoconjunctivitis | 3 | 8 |
| Cutaneous sclerosis | 4 | 13 |
| Esophageal stricture | <1 | 1 |
| Bronchiolitis obliterans syndrome | <1 | 7 |
| Eosinophilia | 14 | 20 |
| Bronchiolitis obliterans organizing pneumonia | 2 | 4 |
| Other characteristics | ||
| Progressive onset | 13 | |
| Quiescent onset | 60 | |
| De novo onset | 27 | |
| On steroids at diagnosis | 34 | |
| Platelets < 100,000 at diagnosis | 31 | |