Summary of cited references for thrombophilia states and markers of coagulation activation as predictors of VTE outcome in children and adults.
| Predictors . | Outcomes . | Adult Literature . | Pediatric Literature . |
|---|---|---|---|
| Abbreviations: VTE, venous thromboembolism; OR, odds ratio; FV, factor V; PT, prothrombin; FVIII, factor VIII; PTS, post-thrombotic syndrome; Hcy, homocysteine; APA(S), antiphospholipid antibody (syndrome). | |||
| Intrinsic anticoagulant deficiencies | Recurrent VTE | 20–23 | 63 |
| Homozygous FV Leiden | Recurrent VTE | 32, 37 | 63 |
| Homozygous PT G20210A | Recurrent VTE | — | — |
| PT G20210A (any) | Recurrent VTE | — | 64 |
| Elevated FVIII | Recurrent VTE, PTS, persistent thrombosis | 44 | 5 |
| Elevated Hcy | Recurrent VTE | 48 | — |
| APA(S) | Recurrent VTE | 50–53 | 66, 69, 70 |
| Multi-trait thrombophilia | Recurrent VTE | 35, 54, 55 | 63 |
| Acutely elevated D-dimer | Recurrent VTE, PTS, persistent thrombosis | — | 5 |
| Elevated D-dimer at 3-6 months post-event | Recurrent VTE, PTS, persistent thrombosis | 56–58 | 5 |
| Predictors . | Outcomes . | Adult Literature . | Pediatric Literature . |
|---|---|---|---|
| Abbreviations: VTE, venous thromboembolism; OR, odds ratio; FV, factor V; PT, prothrombin; FVIII, factor VIII; PTS, post-thrombotic syndrome; Hcy, homocysteine; APA(S), antiphospholipid antibody (syndrome). | |||
| Intrinsic anticoagulant deficiencies | Recurrent VTE | 20–23 | 63 |
| Homozygous FV Leiden | Recurrent VTE | 32, 37 | 63 |
| Homozygous PT G20210A | Recurrent VTE | — | — |
| PT G20210A (any) | Recurrent VTE | — | 64 |
| Elevated FVIII | Recurrent VTE, PTS, persistent thrombosis | 44 | 5 |
| Elevated Hcy | Recurrent VTE | 48 | — |
| APA(S) | Recurrent VTE | 50–53 | 66, 69, 70 |
| Multi-trait thrombophilia | Recurrent VTE | 35, 54, 55 | 63 |
| Acutely elevated D-dimer | Recurrent VTE, PTS, persistent thrombosis | — | 5 |
| Elevated D-dimer at 3-6 months post-event | Recurrent VTE, PTS, persistent thrombosis | 56–58 | 5 |