Translocations and fusion proteins in alk-positive anaplastic large cell lymphoma.
| Translocation . | Partner gene . | Frequency, % . | ALK staining pattern . |
|---|---|---|---|
| t(2;5) | Nucleophosmin (NPM) | 75 | Cytoplasmic + nuclear + nucleolar |
| t(1;2) | Tropomyosin 3 (TPM3) | 10–20 | Cytoplasmic |
| t(2;3) | TRK fused gene (TFG) | 2–5 | Cytoplasmic |
| inv (2) | ATIC (Pur H gene) | 2–5 | Cytoplasmic |
| t(2;17) | Clathrin heavy chain (CLTC) | 2–5 | Cytoplasmic/granular |
| t(2;22) | Myosin heavy chain (MYH9) | rare | Cytoplasmic |
| t(2;17) | ALK lymphoma oligomerization partner on chromosome 17 (ALO17) | rare | Cytoplasmic |
| t(2;19) | Tropomyosin 4 (TPM4) | rare | Cytoplasmic |
| t(2;X) | Moesin (MSN) | rare | Membrane-associated |
| Translocation . | Partner gene . | Frequency, % . | ALK staining pattern . |
|---|---|---|---|
| t(2;5) | Nucleophosmin (NPM) | 75 | Cytoplasmic + nuclear + nucleolar |
| t(1;2) | Tropomyosin 3 (TPM3) | 10–20 | Cytoplasmic |
| t(2;3) | TRK fused gene (TFG) | 2–5 | Cytoplasmic |
| inv (2) | ATIC (Pur H gene) | 2–5 | Cytoplasmic |
| t(2;17) | Clathrin heavy chain (CLTC) | 2–5 | Cytoplasmic/granular |
| t(2;22) | Myosin heavy chain (MYH9) | rare | Cytoplasmic |
| t(2;17) | ALK lymphoma oligomerization partner on chromosome 17 (ALO17) | rare | Cytoplasmic |
| t(2;19) | Tropomyosin 4 (TPM4) | rare | Cytoplasmic |
| t(2;X) | Moesin (MSN) | rare | Membrane-associated |