Summary of the main features of the use of platelet transfusions in three multicenter RCTs that have either recently been completed (PLADO), stopped (SToP), or is ongoing (TOPPS) evaluating different strategies for use in thrombocytopenic patients with a hypoproliferative marrow.
| . | PLADO . | SToP . | TOPPS . |
|---|---|---|---|
| Abbreviations: PLADO, Prophylactic PLAtelet Dose study; SToP, Strategies for the Transfusion of Platelets study; TOPPS, Trial Of Prophylactic Platelets Study; N/A, not applicable; DSMB, data safety monitoring board; WHO, World Health Organization. | |||
| Type of platelet transfusion intervention | Prophylactic | Prophylactic | Therapeutic vs prophylactic |
| Primary Endpoint | WHO Bleeding (grade 2 or greater) | WHO Bleeding (grade 2 or greater) | WHO Bleeding (grade 2 or greater) |
| Projected sample size, n | 1350 (3 arms) | 270 (2 arms) | 300 (2 arms) |
| Arm 1 intervention | 1.1 × 1011 platelets/m2 | 1.5 to 2.9 × 1011 platelets | Prophylactic platelet transfusions with a trigger of 10 x 109/L |
| Arm 2 intervention | 2.2 × 1011 platelets/m2 | 3.0 to 6.0 × 1011 platelets | Therapeutic platelet transfusions only |
| Arm 3 intervention | 4.4 × 1011 platelets/m2 | N/A | N/A |
| Study Status | Concluded; data being analyzed | Stopped by DSMB (n = 130) | Ongoing |
| . | PLADO . | SToP . | TOPPS . |
|---|---|---|---|
| Abbreviations: PLADO, Prophylactic PLAtelet Dose study; SToP, Strategies for the Transfusion of Platelets study; TOPPS, Trial Of Prophylactic Platelets Study; N/A, not applicable; DSMB, data safety monitoring board; WHO, World Health Organization. | |||
| Type of platelet transfusion intervention | Prophylactic | Prophylactic | Therapeutic vs prophylactic |
| Primary Endpoint | WHO Bleeding (grade 2 or greater) | WHO Bleeding (grade 2 or greater) | WHO Bleeding (grade 2 or greater) |
| Projected sample size, n | 1350 (3 arms) | 270 (2 arms) | 300 (2 arms) |
| Arm 1 intervention | 1.1 × 1011 platelets/m2 | 1.5 to 2.9 × 1011 platelets | Prophylactic platelet transfusions with a trigger of 10 x 109/L |
| Arm 2 intervention | 2.2 × 1011 platelets/m2 | 3.0 to 6.0 × 1011 platelets | Therapeutic platelet transfusions only |
| Arm 3 intervention | 4.4 × 1011 platelets/m2 | N/A | N/A |
| Study Status | Concluded; data being analyzed | Stopped by DSMB (n = 130) | Ongoing |