Table 2.

Summary of some of the approaches available for the treatment of bleeding in patients with thrombocytopenia.

Prophylactic platelet transfusions 
Therapeutic platelet transfusions 
HLA-matched platelets for platelet transfusion-refractory patients 
Pharmacologic agents that potentially can enhance intrinsic 
hemostatic function: 

  • Corticosteroids

  • Estrogens

  • DDAVP

  • Aprotinin

  • Tranexamic acid

  • Epsilon amino caproic acid (EACA)

 
Biologic Agents that can enhance hemostatic function: 

  • Platelet substitutes27 

  • Factor VIIa28 

 
Agents that can improve the intrinsic platelet count: 

  • Thrombopoietic growth factors29 

  • Other chemokines (e.g., IL-11)

 
Prophylactic platelet transfusions 
Therapeutic platelet transfusions 
HLA-matched platelets for platelet transfusion-refractory patients 
Pharmacologic agents that potentially can enhance intrinsic 
hemostatic function: 

  • Corticosteroids

  • Estrogens

  • DDAVP

  • Aprotinin

  • Tranexamic acid

  • Epsilon amino caproic acid (EACA)

 
Biologic Agents that can enhance hemostatic function: 

  • Platelet substitutes27 

  • Factor VIIa28 

 
Agents that can improve the intrinsic platelet count: 

  • Thrombopoietic growth factors29 

  • Other chemokines (e.g., IL-11)

 
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