Examples of cooperating mutations modified according to the two-hit model of Gilliland et al.13
| Class I mutations (interfering with transcription) . | Cooperating class II mutations (mediating proliferation) . |
|---|---|
| PML-RARA/t(15;17) | FLT3-ITD FLT3-TKD |
| RUNX1/RUNX1T1/t(8;21) or RUNX1 rearrangements with other partner genes | KIT-TKD mutation JAK2V617F FLT3-ITD |
| CBFB-MYH11/inv(16)/t(16;16) | KIT-TKD mutation NRAS mutation |
| CEBPA mutations | FLT3-ITD |
| RUNX1 mutations (= AML1, located on 21q22) | FLT3-ITD |
| Class I mutations (interfering with transcription) . | Cooperating class II mutations (mediating proliferation) . |
|---|---|
| PML-RARA/t(15;17) | FLT3-ITD FLT3-TKD |
| RUNX1/RUNX1T1/t(8;21) or RUNX1 rearrangements with other partner genes | KIT-TKD mutation JAK2V617F FLT3-ITD |
| CBFB-MYH11/inv(16)/t(16;16) | KIT-TKD mutation NRAS mutation |
| CEBPA mutations | FLT3-ITD |
| RUNX1 mutations (= AML1, located on 21q22) | FLT3-ITD |