Clinical findings of DENV, CHKV, and ZIKV infections in HSCT recipients and oncohematological patients
| Patient group . | UD . | Age (y) . | Sex . | Days to diagnosis* . | Symptoms . | Platelets (×109/L) . | Virus . | Sample . | Viremia/viruria duration . | Complications . |
|---|---|---|---|---|---|---|---|---|---|---|
| HSCT MRD | AML | 30 | M | 1 | Fever, exanthema, nausea, vomiting, myalgia, arthralgia | 168 000 | CHKV | P | <30 d | None |
| HSCT MUD | ALL | 4 | F | 4 | Fever, headache, diarrhea, myalgia, arthralgia, GI bleeding | 14 000 | DENV2 | P | <30 d | Enterorrhagia |
| HSCT MRD | ALL | 46 | F | >30 | Fever, headache, nausea, vomiting myalgia, abdominal pain | 19 000 | DENV | P | Unknown | None |
| HSCT AUTO | SS | 48 | M | 18 | Fever, headache, exanthema, myalgia, arthralgia | 114 000 | ZIKV | U | <7 d | None |
| HSCT MRD | ALL | 34 | F | 7 | Exanthema, myalgia, somnolence | 245 000 | ZIKV | P+U | 7 d (U) | None |
| Oncohematological | Testicular tumor | 17 | M | 3 | Fever, exanthema, headache, myalgia, arthralgia, lethargy | 133 000 | CHKV | P | 3 d (P) | None |
| Onco hematological | NHL | M | 18 | Fever, headache, nausea, lethargy, somnolence | 16 000 | DENV1 | P | ≥30 d (P + U) | Weight loss, persistent leukopenia | |
| Oncohematological | AML | 15 | F | 7 | Fever, nausea, exanthema | 15 200 | ZIKV | P, U | 7 d (P + U) | Delayed engraftment |
| Oncohematological | ALL | 7 | F | 7 | Fever, exanthema, conjunctivitis, petechiae | 16 000 | ZIKV | P, U | 7 d (U) | None |
| Patient group . | UD . | Age (y) . | Sex . | Days to diagnosis* . | Symptoms . | Platelets (×109/L) . | Virus . | Sample . | Viremia/viruria duration . | Complications . |
|---|---|---|---|---|---|---|---|---|---|---|
| HSCT MRD | AML | 30 | M | 1 | Fever, exanthema, nausea, vomiting, myalgia, arthralgia | 168 000 | CHKV | P | <30 d | None |
| HSCT MUD | ALL | 4 | F | 4 | Fever, headache, diarrhea, myalgia, arthralgia, GI bleeding | 14 000 | DENV2 | P | <30 d | Enterorrhagia |
| HSCT MRD | ALL | 46 | F | >30 | Fever, headache, nausea, vomiting myalgia, abdominal pain | 19 000 | DENV | P | Unknown | None |
| HSCT AUTO | SS | 48 | M | 18 | Fever, headache, exanthema, myalgia, arthralgia | 114 000 | ZIKV | U | <7 d | None |
| HSCT MRD | ALL | 34 | F | 7 | Exanthema, myalgia, somnolence | 245 000 | ZIKV | P+U | 7 d (U) | None |
| Oncohematological | Testicular tumor | 17 | M | 3 | Fever, exanthema, headache, myalgia, arthralgia, lethargy | 133 000 | CHKV | P | 3 d (P) | None |
| Onco hematological | NHL | M | 18 | Fever, headache, nausea, lethargy, somnolence | 16 000 | DENV1 | P | ≥30 d (P + U) | Weight loss, persistent leukopenia | |
| Oncohematological | AML | 15 | F | 7 | Fever, nausea, exanthema | 15 200 | ZIKV | P, U | 7 d (P + U) | Delayed engraftment |
| Oncohematological | ALL | 7 | F | 7 | Fever, exanthema, conjunctivitis, petechiae | 16 000 | ZIKV | P, U | 7 d (U) | None |
ALL, acute lymphocytic leukemia; AML, acute myeloid leukemia; F, female; GI, gastrointestinal; M, male; MRD, matched related donor; MUD, matched unrelated donor; P, plasma; SS, systemic sclerosis; U, urine; UD, underlying disease.
Interval from symptom onset to diagnostic sampling.