Table 1. Baseline characteristics... | American Society of Hematology

Table 1.

Baseline characteristics

Patient	Cohort	Age (y)	Sex	Disease type	Disease-related complications/comorbidities	HCT-CI	Donor				HLA match	CD34 dose (× 10⁶/kg)	CD3 dose (× 10⁸/kg)
Patient	Cohort	Age (y)	Sex	Disease type	Disease-related complications/comorbidities	HCT-CI	Age (y)	Sex	Relation	HbS (%)	HLA match	CD34 dose (× 10⁶/kg)	CD3 dose (× 10⁸/kg)
1	1	44	F	HbSS	ESRD on PD, pHTN, diastolic dysfunction, iron overload, history of ACS/VOC	6	38	F	Sister	39	5/10	15.9	5.50
2	1	20	M	HbSS	pHTN, iron overload, stroke, moyamoya	10	47	F	Mother	40	6/10	15.0	2.65
3	1	36	F	HbSS	pHTN, history of VOC, RA	6	46	F	Sister	0	7/10	9.76	2.83
4	2	37	F	HbSS	Iron overload, history of VOC, MS	7	66	F	Mother	39	8/10	10.2	3.78
5	2	47	M	HbSS	Systolic dysfunction, cirrhosis/NRH, history of ACS/VOC, stroke	7	60	F	Sister	38	6/10	11.9	7.93
6	2	36	M	HbSS	Systolic dysfunction, iron overload, history of ACS/VOC, stroke	8	28	M	Brother	38	7/10	28.0	5.01
7	2	31	F	HbSS	Iron overload, moyamoya	3	60	F	Mother	38	7/10	13.0	8.07
8	2	35	M	β-thal	Iron overload	3	67	F	Mother	0	6/10	8.79	3.75
9	2	21	M	HbSS	Iron overload, history of ACS/VOC, stroke, moyamoya	7	51	F	Mother	39	5/10	12.2	3.51
10	2	25	M	β-thal	Iron overload	7	55	F	Mother	0	7/10	7.04	1.86
11	2	24	M	HbSS	ESRD on HD, systolic dysfunction, iron overload, history of ACS/VOC	6	20	M	Brother	39	7/10	13.4	2.59
12	3	37	M	HbSS	ESRD on PD, iron overload, history of VOC	6	61	F	Mother	34	8/10	25.6	4.73
13	3	41	M	HbSS	ESRD on PD, systolic and diastolic dysfunction, iron overload, history of VOC	10	45	F	Sister	0	8/10	15.9	5.08
14	3	37	M	HbSS	CRI, iron overload, history of ACS/VOC, stroke	3	56	F	Mother	40	7/10	10.2	2.98
15	3	31	F	HbSS	pHTN, iron overload, history of ACS/VOC, TIA	7	30	F	Sister	42	7/10	15.1	4.00
16	3	56	F	HbSC	Iron overload, history of ACS/VOC	3	31	M	Son	40	8/10	29.7	3.78
17	3	26	M	HbSS	History of ACS/VOC	3	51	F	Mother	39	6/10	16.8	3.948
18	3	20	F	HbSS	Iron overload, history of ACS/VOC	2	51	F	Mother	40	6/10	10.2	6.14
19	3	47	F	HbSS	CRI, diastolic dysfunction, iron overload, history of ACS/VOC	9	23	F	Sister	0	5/10	16.6	2.95
20	3	34	F	HbS β⁰-thal	Cirrhosis, history of VOC	8	30	M	Brother	0	8/10	9.70	5.28
21	3	27	M	HbSS	Iron overload, history of ACS/VOC, stroke, moyamoya	6	52	F	Mother	39	5/10	11.5	3.65
22	3	36	M	HbSS	Iron overload, history of ACS/VOC	5	64	M	Father	35	5/10	12.2	2.42
23	3	42	M	HbSS	pHTN, systolic dysfunction, history of ACS	6	23	F	Sister	0	7/10	10.1	6.12

Patient	Cohort	Age (y)	Sex	Disease type	Disease-related complications/comorbidities	HCT-CI	Donor				HLA match	CD34 dose (× 10⁶/kg)	CD3 dose (× 10⁸/kg)
Patient	Cohort	Age (y)	Sex	Disease type	Disease-related complications/comorbidities	HCT-CI	Age (y)	Sex	Relation	HbS (%)	HLA match	CD34 dose (× 10⁶/kg)	CD3 dose (× 10⁸/kg)
1	1	44	F	HbSS	ESRD on PD, pHTN, diastolic dysfunction, iron overload, history of ACS/VOC	6	38	F	Sister	39	5/10	15.9	5.50
2	1	20	M	HbSS	pHTN, iron overload, stroke, moyamoya	10	47	F	Mother	40	6/10	15.0	2.65
3	1	36	F	HbSS	pHTN, history of VOC, RA	6	46	F	Sister	0	7/10	9.76	2.83
4	2	37	F	HbSS	Iron overload, history of VOC, MS	7	66	F	Mother	39	8/10	10.2	3.78
5	2	47	M	HbSS	Systolic dysfunction, cirrhosis/NRH, history of ACS/VOC, stroke	7	60	F	Sister	38	6/10	11.9	7.93
6	2	36	M	HbSS	Systolic dysfunction, iron overload, history of ACS/VOC, stroke	8	28	M	Brother	38	7/10	28.0	5.01
7	2	31	F	HbSS	Iron overload, moyamoya	3	60	F	Mother	38	7/10	13.0	8.07
8	2	35	M	β-thal	Iron overload	3	67	F	Mother	0	6/10	8.79	3.75
9	2	21	M	HbSS	Iron overload, history of ACS/VOC, stroke, moyamoya	7	51	F	Mother	39	5/10	12.2	3.51
10	2	25	M	β-thal	Iron overload	7	55	F	Mother	0	7/10	7.04	1.86
11	2	24	M	HbSS	ESRD on HD, systolic dysfunction, iron overload, history of ACS/VOC	6	20	M	Brother	39	7/10	13.4	2.59
12	3	37	M	HbSS	ESRD on PD, iron overload, history of VOC	6	61	F	Mother	34	8/10	25.6	4.73
13	3	41	M	HbSS	ESRD on PD, systolic and diastolic dysfunction, iron overload, history of VOC	10	45	F	Sister	0	8/10	15.9	5.08
14	3	37	M	HbSS	CRI, iron overload, history of ACS/VOC, stroke	3	56	F	Mother	40	7/10	10.2	2.98
15	3	31	F	HbSS	pHTN, iron overload, history of ACS/VOC, TIA	7	30	F	Sister	42	7/10	15.1	4.00
16	3	56	F	HbSC	Iron overload, history of ACS/VOC	3	31	M	Son	40	8/10	29.7	3.78
17	3	26	M	HbSS	History of ACS/VOC	3	51	F	Mother	39	6/10	16.8	3.948
18	3	20	F	HbSS	Iron overload, history of ACS/VOC	2	51	F	Mother	40	6/10	10.2	6.14
19	3	47	F	HbSS	CRI, diastolic dysfunction, iron overload, history of ACS/VOC	9	23	F	Sister	0	5/10	16.6	2.95
20	3	34	F	HbS β⁰-thal	Cirrhosis, history of VOC	8	30	M	Brother	0	8/10	9.70	5.28
21	3	27	M	HbSS	Iron overload, history of ACS/VOC, stroke, moyamoya	6	52	F	Mother	39	5/10	11.5	3.65
22	3	36	M	HbSS	Iron overload, history of ACS/VOC	5	64	M	Father	35	5/10	12.2	2.42
23	3	42	M	HbSS	pHTN, systolic dysfunction, history of ACS	6	23	F	Sister	0	7/10	10.1	6.12

ACS, acute chest syndrome; β-thal, β-thalassemia; CRI, chronic renal insufficiency; ESRD, end-stage renal disease; F, female; HbS, hemoglobin S; HbSC, compound heterozygous HbS and HbC disease; HbSS, homozygous sickle cell disease; HbS β⁰-thal, compound heterozygous HbS and β⁰-thalassemia disease; HCT-CI, hematopoietic cell transplantation–specific comorbidity index; HD, hemodialysis; M, male; MS, multiple sclerosis; NRH, nodular regenerative hyperplasia; PD, peritoneal dialysis; pHTN, pulmonary hypertension; RA, rheumatoid arthritis; TIA, transient ischemic attack; VOC, vaso-occlusive crisis.

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