Table 1. Donor-recipient HLA-matching... | American Society of Hematology

Table 1.

Donor-recipient HLA-matching status

	PTCy regimen, n (%)	ATG regimen, n (%)	P
HLA-matching status in the entire population	N = 313	N = 196
HLA-A
Antigen mismatch	260 (83)	170 (87)	.26
Antigen match	53 (17)	26 (13)
HLA-B
Antigen mismatch	277 (88)	177 (90)	.52
Antigen match	36 (12)	19 (10)
HLA-C
Antigen mismatch	260 (83)	157 (80)	.40
Antigen match	53 (17)	39 (20)
HLA-DRB1
Antigen mismatch	260 (83)	158 (81)	.48
Antigen match	53 (17)	38 (19)
HLA-matching status in subgroup with HLA high-resolution imputation	N = 258	N = 160
HLA-A
Antigen* mismatch	222 (86)	149 (93)	.03
Antigen match	36 (14)	11 (7)
Allele† mismatch	229 (88)	151 (94)	.07
Allele match	29 (12)	9 (6)
HLA-B
Antigen mismatch	235 (91)	146 (91)	.70
Antigen match	23 (9)	14 (9)
Allele mismatch	239 (93)	145 (91)	.46
Allele match	19 (7)	15 (9)
HLA-C
Antigen mismatch	226 (88)	133 (83)	.19
Antigen match	32 (12)	27 (17)
Allele mismatch	236 (91)	139 (87)	.13
Allele match	22 (9)	21 (13)
HLA-DRB1
Antigen mismatch	221 (86)	140 (87)	.96
Antigen match	37 (14)	20 (13)
Allele mismatch	236 (91)	148 (92)	.71
Allele match	22 (9)	12 (8)
NK alloreactivity in GVL vector
Yes	97 (38)	67 (42)	.38
No	161 (62)	93 (58)

	PTCy regimen, n (%)	ATG regimen, n (%)	P
HLA-matching status in the entire population	N = 313	N = 196
HLA-A
Antigen mismatch	260 (83)	170 (87)	.26
Antigen match	53 (17)	26 (13)
HLA-B
Antigen mismatch	277 (88)	177 (90)	.52
Antigen match	36 (12)	19 (10)
HLA-C
Antigen mismatch	260 (83)	157 (80)	.40
Antigen match	53 (17)	39 (20)
HLA-DRB1
Antigen mismatch	260 (83)	158 (81)	.48
Antigen match	53 (17)	38 (19)
HLA-matching status in subgroup with HLA high-resolution imputation	N = 258	N = 160
HLA-A
Antigen* mismatch	222 (86)	149 (93)	.03
Antigen match	36 (14)	11 (7)
Allele† mismatch	229 (88)	151 (94)	.07
Allele match	29 (12)	9 (6)
HLA-B
Antigen mismatch	235 (91)	146 (91)	.70
Antigen match	23 (9)	14 (9)
Allele mismatch	239 (93)	145 (91)	.46
Allele match	19 (7)	15 (9)
HLA-C
Antigen mismatch	226 (88)	133 (83)	.19
Antigen match	32 (12)	27 (17)
Allele mismatch	236 (91)	139 (87)	.13
Allele match	22 (9)	21 (13)
HLA-DRB1
Antigen mismatch	221 (86)	140 (87)	.96
Antigen match	37 (14)	20 (13)
Allele mismatch	236 (91)	148 (92)	.71
Allele match	22 (9)	12 (8)
NK alloreactivity in GVL vector
Yes	97 (38)	67 (42)	.38
No	161 (62)	93 (58)

First field HLA typing as reported by the transplant centers.

†

Second field HLA typing was reported by the transplant centers in 174 pairs (134 PTCy, 40 ATG). For the remaining 244 pairs, allele level matching was imputed by in silico simulation as described in “Methods.”

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