Bleeding outcomes by average platelet AUC during anticoagulant exposure
| Average platelet AUC (n = 141) . | Major bleeding (%) . | P . | Overall bleeding (%) . | P . |
|---|---|---|---|---|
| 30-50 × 103/μL (n = 30) | 0 (0) | 11 (8) | ||
| 50-60 × 103/μL (n = 59) | 4 (3) | .28 | 27 (19) | .47 |
| 60-80 × 103/μL (n = 52) | 1 (1) | 15 (11) |
| Average platelet AUC (n = 141) . | Major bleeding (%) . | P . | Overall bleeding (%) . | P . |
|---|---|---|---|---|
| 30-50 × 103/μL (n = 30) | 0 (0) | 11 (8) | ||
| 50-60 × 103/μL (n = 59) | 4 (3) | .28 | 27 (19) | .47 |
| 60-80 × 103/μL (n = 52) | 1 (1) | 15 (11) |
As an estimate of the degree to which the target platelet count was achieved, all platelet values from the onset of thrombocytopenia until recovery were plotted against time in groups 1a, 1b, and 2b. An AUC was calculated (AUCN = (PN+1 + PN) * (TN+1 − TN)/2; P = platelet; T = date/time). The average platelet AUC value was then derived for the duration of thrombocytopenia (AUCAVE = SUM(AUC1:AUCN)/(TN+1 − T1)). If anticoagulation was stopped prior to platelet recovery, only values prior to the stop date were used in the calculation. The risk of bleeding was compared among various groups using Fisher’s exact test.