Table 2.

Major and minor BTK clones detected in each patient

Major cloneMinor clone
nt changeaa changeCCF (%)nt changeaa changeCCF (%)
CLL011 1442C>G C481S 97 None   
CLL012 946T>C T316A 100 1442C>G C481S 2.9 
    1443A>G C481R 1.5 
CLL019* 1442C>T C481Y 100† 1442C>G C481S 11.6 
CLL022 1442C>T C481Y 56.7 None   
CLL015 1443A>T C481S 90.7 1442C>G C481S 8.5 
    1443A>G C481R 2.5 
Major cloneMinor clone
nt changeaa changeCCF (%)nt changeaa changeCCF (%)
CLL011 1442C>G C481S 97 None   
CLL012 946T>C T316A 100 1442C>G C481S 2.9 
    1443A>G C481R 1.5 
CLL019* 1442C>T C481Y 100† 1442C>G C481S 11.6 
CLL022 1442C>T C481Y 56.7 None   
CLL015 1443A>T C481S 90.7 1442C>G C481S 8.5 
    1443A>G C481R 2.5 
*

In CLL019, the major clone C481Y was found in the RT (liver), whereas the minor clone C481S was in the PB.

†

Tumor cellularity on tissue sections was based on microscopic estimation, whereas tumor cellularity in PB/BM was based on flow cytometric determination.

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