Incident rates for ONFH, pre- and posthydroxyurea era, among SCD patients, California, 1991-2013
| . | Prehydroxyurea (1991-2000) . | Posthydroxyurea (2001-2013) . | ||||
|---|---|---|---|---|---|---|
| Age category (years) . | ONFH cases . | Incident rate* . | 95% CI . | ONFH cases . | Incident rate* . | 95% CI . |
| <10 | 46 | 0.85 | 0.63-1.10 | 31 | 0.46 | 0.32-0.64 |
| 10 to <20 | 137 | 2.65 | 2.23-3.12 | 145 | 1.27 | 1.07-1.49 |
| 20 to <30 | 151 | 2.52 | 1.93-2.70 | 236 | 2.11 | 1.86-2.40 |
| 30 to <40 | 133 | 2.48 | 2.08-2.93 | 158 | 1.66 | 1.42-1.93 |
| 40 to <50 | 73 | 2.58 | 2.04-3.23 | 110 | 1.44 | 1.19-1.73 |
| 50 to <60 | 38 | 4.43 | 3.18-6.02 | 69 | 1.78 | 1.39-2.23 |
| ≥60 | 10 | 6.51 | 3.31-11.6 | 19 | 1.94 | 1.21-2.98 |
| Total | 588 | 2.37 | 2.18-2.56 | 768 | 1.52 | 1.41-1.63 |
| . | Prehydroxyurea (1991-2000) . | Posthydroxyurea (2001-2013) . | ||||
|---|---|---|---|---|---|---|
| Age category (years) . | ONFH cases . | Incident rate* . | 95% CI . | ONFH cases . | Incident rate* . | 95% CI . |
| <10 | 46 | 0.85 | 0.63-1.10 | 31 | 0.46 | 0.32-0.64 |
| 10 to <20 | 137 | 2.65 | 2.23-3.12 | 145 | 1.27 | 1.07-1.49 |
| 20 to <30 | 151 | 2.52 | 1.93-2.70 | 236 | 2.11 | 1.86-2.40 |
| 30 to <40 | 133 | 2.48 | 2.08-2.93 | 158 | 1.66 | 1.42-1.93 |
| 40 to <50 | 73 | 2.58 | 2.04-3.23 | 110 | 1.44 | 1.19-1.73 |
| 50 to <60 | 38 | 4.43 | 3.18-6.02 | 69 | 1.78 | 1.39-2.23 |
| ≥60 | 10 | 6.51 | 3.31-11.6 | 19 | 1.94 | 1.21-2.98 |
| Total | 588 | 2.37 | 2.18-2.56 | 768 | 1.52 | 1.41-1.63 |
Incident rate per 100 person-years.