Dominant gene transcripts related to immune functions in pltLys-iTreg and purTGFβ-iTreg cells
| Molecule . | pltLys-iTreg/purTGFβ-iTreg (fold change) . | Functions . |
|---|---|---|
| Gzmb | 30.99 | Is important for CD8, natural killer T, and subsets of Treg cell function52 |
| Ifng | 29.18 | Plays a major role in immunosuppression mediated by IFN-γ–producing Tregs65 |
| Il2 | 17.94 | Essential for Treg cell function66 |
| Chemokine (C-C motif) ligand 3 (Ccl3) | 8.97 | Essential for regulation of Foxp3 stability67 |
| Fas ligand (Fasl) | 4.78 | Plays a critical role in cell-killing activity and enhances Treg cell suppressive activity68 |
| Neuritin 1 (Nrn1) | 4.51 | Is responsible for the persistence of Treg cells69 |
| Tumor necrosis factor superfamily, member 14 (Tnfsf14) | 4.49 | Is important for Treg suppressive function70 |
| Nuclear receptor subfamily 4, group A, member 2 (Nr4A2) | 4.06 | Plays important role in Treg cell development and suppressive functions71 |
| Thyroglobulin (Tg) | 4.03 | Regulates Treg cell function in preventing autoimmune thyroiditis72 |
| Cytotoxic and Treg cell molecule (Crtam) | 3.51 | Regulates CD8, natural killer, and Treg cell-killing functions73 |
| CD36 antigen (Cd36) | 3.47 | Plays a role in Treg induction74 |
| CD83 antigen (Cd83) | 3.24 | Involved in Treg suppressive function75 |
| CD40 antigen (Cd40) | −6.47 | Plays roles in Treg differentiation76 |
| Cytotoxic T lymphocyte–associated protein 2 β (Ctla2b) | −5.21 | Is one of the serine protease inhibitors77 |
| Acyl-CoA synthetase bubblegum family member 1 (Acsbg1) | −3.33 | Plays roles in T-cell demethylation (T helper 1 [Th1], Th17, Treg, etc)78 |
| Molecule . | pltLys-iTreg/purTGFβ-iTreg (fold change) . | Functions . |
|---|---|---|
| Gzmb | 30.99 | Is important for CD8, natural killer T, and subsets of Treg cell function52 |
| Ifng | 29.18 | Plays a major role in immunosuppression mediated by IFN-γ–producing Tregs65 |
| Il2 | 17.94 | Essential for Treg cell function66 |
| Chemokine (C-C motif) ligand 3 (Ccl3) | 8.97 | Essential for regulation of Foxp3 stability67 |
| Fas ligand (Fasl) | 4.78 | Plays a critical role in cell-killing activity and enhances Treg cell suppressive activity68 |
| Neuritin 1 (Nrn1) | 4.51 | Is responsible for the persistence of Treg cells69 |
| Tumor necrosis factor superfamily, member 14 (Tnfsf14) | 4.49 | Is important for Treg suppressive function70 |
| Nuclear receptor subfamily 4, group A, member 2 (Nr4A2) | 4.06 | Plays important role in Treg cell development and suppressive functions71 |
| Thyroglobulin (Tg) | 4.03 | Regulates Treg cell function in preventing autoimmune thyroiditis72 |
| Cytotoxic and Treg cell molecule (Crtam) | 3.51 | Regulates CD8, natural killer, and Treg cell-killing functions73 |
| CD36 antigen (Cd36) | 3.47 | Plays a role in Treg induction74 |
| CD83 antigen (Cd83) | 3.24 | Involved in Treg suppressive function75 |
| CD40 antigen (Cd40) | −6.47 | Plays roles in Treg differentiation76 |
| Cytotoxic T lymphocyte–associated protein 2 β (Ctla2b) | −5.21 | Is one of the serine protease inhibitors77 |
| Acyl-CoA synthetase bubblegum family member 1 (Acsbg1) | −3.33 | Plays roles in T-cell demethylation (T helper 1 [Th1], Th17, Treg, etc)78 |