Table 1. Baseline demographic and... | American Society of Hematology

Table 1.

Baseline demographic and disease characteristics

Baseline characteristic	High-risk smoldering myeloma (n = 18)
Baseline characteristic	No.	%
Median age, y (range)	59 (40-73)
Sex
Male	9	50
Female	9	50
Race
White	14	89
African American	4	11
Risk of progression
Mayo Clinic risk model*
High	3	17
Low/intermediate	15	83
Spanish PETHEMA risk model†
High	16	89
Low/intermediate	2	11
MM by the 2014 IMWG criteria¹¹	6	33
Heavy chain isotype
IgG	16	89
IgA	1	5.5
Light chain	1	5.5
Light chain isotype
κ	13	72
Λ	5	28
FISH/cytogenetics
13q14 deletion	4	22
17p13.1 deletion	1	6
IgH translocation	4	22
Median serum monoclonal protein, g/dL (range)	1.9 (1.0-5.3)
Bone marrow plasma cell infiltration
Median, % (range)	30 (12.5-65)
10-60	12	67
>60	6	33

Baseline characteristic	High-risk smoldering myeloma (n = 18)
Baseline characteristic	No.	%
Median age, y (range)	59 (40-73)
Sex
Male	9	50
Female	9	50
Race
White	14	89
African American	4	11
Risk of progression
Mayo Clinic risk model*
High	3	17
Low/intermediate	15	83
Spanish PETHEMA risk model†
High	16	89
Low/intermediate	2	11
MM by the 2014 IMWG criteria¹¹	6	33
Heavy chain isotype
IgG	16	89
IgA	1	5.5
Light chain	1	5.5
Light chain isotype
κ	13	72
Λ	5	28
FISH/cytogenetics
13q14 deletion	4	22
17p13.1 deletion	1	6
IgH translocation	4	22
Median serum monoclonal protein, g/dL (range)	1.9 (1.0-5.3)
Bone marrow plasma cell infiltration
Median, % (range)	30 (12.5-65)
10-60	12	67
>60	6	33

FISH, fluorescent in situ hybridization; Ig, immunoglobulin.

High-risk features include bone marrow plasma cell infiltration >10%, serum monoclonal protein >3 g/dL, and free light chain ratio >8 or <0.125.

High-risk features include 95% or more plasma cells with abnormal immunophenotype by flow cytometry and serum immunoparesis.