Univariable Cox proportional hazards models for OS, EFS, and DFS for the FLT3-ITD subgroup
| . | n (events) . | HR . | 95% CI . | 2-sided P value . |
|---|---|---|---|---|
| OS | ||||
| Race/ethnicity (non-Hispanic white vs other) | 39 (29) | 0.538 | 0.226-1.280 | .16 |
| Sex (female vs male) | 39 (29) | 1.289 | 0.620-2.682 | .50 |
| Age (≥70 y vs <70 y) | 39 (29) | 2.600 | 1.237-5.469 | .01 |
| ELN risk group (CN-AML vs intermediate II) | 34 (24) | 1.230 | 0.504-3.002 | .65 |
| ELN risk group (ELN adverse vs intermediate II) | 34 (24) | 1.764 | 0.211-14.782 | .60 |
| Allelic ratio (≥0.7 vs <0.7) (cutoff at median) | 39 (29) | 1.793 | 0.845-3.807 | .13 |
| EFS | ||||
| Race/ethnicity (non-Hispanic white vs other) | 39 (32) | 0.766 | 0.327-1.787 | .54 |
| Sex (female vs male) | 39 (32) | 1.338 | 0.665-2.691 | .41 |
| Age (≥70 y vs <70 y) | 39 (32) | 2.738 | 1.340-5.596 | .01 |
| ELN risk group (CN-AML vs intermediate II) | 34 (27) | 1.302 | 0.565-3.00 | .54 |
| ELN risk group (ELN adverse vs intermediate II) | 34 (27) | 3.789 | 0.441-32.554 | .22 |
| Allelic ratio (≥ 0.7 vs < 0.7) (cutoff at median) | 39 (32) | 1.665 | 0.823-3.366 | .16 |
| DFS | ||||
| Race/ethnicity (non-Hispanic white vs other) | 29 (22) | 0.426 | 0.167-1.082 | .07 |
| Sex (female vs male) | 29 (22) | 1.466 | 0.631-3.405 | .37 |
| Age (≥70 y vs <70 y) | 29 (22) | 2.479 | 1.046-5.876 | .04 |
| ELN risk group (CN-AML vs intermediate II)* | 25 (18) | 2.105 | 0.691-6.410 | .19 |
| Allelic ratio (≥0.7 vs <0.7) (cutoff at median) | 29 (22) | 1.247 | 0.537-2.897 | .61 |
| . | n (events) . | HR . | 95% CI . | 2-sided P value . |
|---|---|---|---|---|
| OS | ||||
| Race/ethnicity (non-Hispanic white vs other) | 39 (29) | 0.538 | 0.226-1.280 | .16 |
| Sex (female vs male) | 39 (29) | 1.289 | 0.620-2.682 | .50 |
| Age (≥70 y vs <70 y) | 39 (29) | 2.600 | 1.237-5.469 | .01 |
| ELN risk group (CN-AML vs intermediate II) | 34 (24) | 1.230 | 0.504-3.002 | .65 |
| ELN risk group (ELN adverse vs intermediate II) | 34 (24) | 1.764 | 0.211-14.782 | .60 |
| Allelic ratio (≥0.7 vs <0.7) (cutoff at median) | 39 (29) | 1.793 | 0.845-3.807 | .13 |
| EFS | ||||
| Race/ethnicity (non-Hispanic white vs other) | 39 (32) | 0.766 | 0.327-1.787 | .54 |
| Sex (female vs male) | 39 (32) | 1.338 | 0.665-2.691 | .41 |
| Age (≥70 y vs <70 y) | 39 (32) | 2.738 | 1.340-5.596 | .01 |
| ELN risk group (CN-AML vs intermediate II) | 34 (27) | 1.302 | 0.565-3.00 | .54 |
| ELN risk group (ELN adverse vs intermediate II) | 34 (27) | 3.789 | 0.441-32.554 | .22 |
| Allelic ratio (≥ 0.7 vs < 0.7) (cutoff at median) | 39 (32) | 1.665 | 0.823-3.366 | .16 |
| DFS | ||||
| Race/ethnicity (non-Hispanic white vs other) | 29 (22) | 0.426 | 0.167-1.082 | .07 |
| Sex (female vs male) | 29 (22) | 1.466 | 0.631-3.405 | .37 |
| Age (≥70 y vs <70 y) | 29 (22) | 2.479 | 1.046-5.876 | .04 |
| ELN risk group (CN-AML vs intermediate II)* | 25 (18) | 2.105 | 0.691-6.410 | .19 |
| Allelic ratio (≥0.7 vs <0.7) (cutoff at median) | 29 (22) | 1.247 | 0.537-2.897 | .61 |
CN, cytogenetically normal; ELN, European LeukemiaNet.
No patients were ELN adverse.