Transplant outcome
| . | Donor source . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | MRD (N = 3511 . | MUD 10/10 (N = 1959) . | MUD 9/10 (N = 549) . | UCB (N = 333) . | Haplo (N = 193) . | |||||
| Graft failure | P < .001 | |||||||||
| No. of patients | 53 | 2% | 29 | 1% | 20 | 4% | 30 | 9% | 11 | 6% |
| Time to engraftment, d | P < .001 | |||||||||
| Median | 16 | 17 | 17 | 23 | 18 | |||||
| IQ range | 13-20 | 14-20 | 14-20 | 17-30 | 15-23 | |||||
| Acute GVHD (maximum grade) | P < .001 | |||||||||
| Grade 0-1 | 2623 | 75% | 1369 | 70% | 374 | 68% | 220 | 66% | 140 | 73% |
| Grade 2-4 | 769 | 22% | 518 | 26% | 156 | 28% | 99 | 30% | 49 | 25% |
| Unknown | 119 | 3% | 72 | 4% | 19 | 3% | 14 | 4% | 4 | 2% |
| Time transplant to acute GVHD, d | P < .11 | |||||||||
| Median | 28 | 27 | 25 | 28 | 29 | |||||
| IQR | 18-47 | 17-43 | 16-42 | 19-38 | 18-48 | |||||
| Chronic GVHD | P < .001 | |||||||||
| Mild | 533 | 15% | 283 | 14% | 81 | 15% | 28 | 8% | 39 | 20% |
| Extensive | 712 | 20% | 310 | 16% | 73 | 13% | 37 | 11% | 18 | 9% |
| Time transplant to chronic GVHD, mo | P < .001 | |||||||||
| Median | 6.0 | 5.4 | 5.6 | 4.9 | 6.4 | |||||
| IQ range | 4.0-9.6 | 3.7-8.3 | 3.7-8.3 | 4.1-6.9 | 4.1-9.6 | |||||
| Outcome at 2 y | ||||||||||
| OS | 59 ± 1% | 57 ± 1% | 49 ± 2% | 44 ± 3% | 57 ± 4% | |||||
| RFS | 53 ± 1% | 53 ± 1% | 44 ± 2% | 41 ± 3% | 52 ± 4% | |||||
| Relapse | 32 ± 1% | 27 ± 1% | 31 ± 2% | 30 ± 3% | 22 ± 3% | |||||
| NRM | 15 ± 1% | 20 ± 1% | 24 ± 2% | 29 ± 3% | 26 ± 3% | |||||
| . | Donor source . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | MRD (N = 3511 . | MUD 10/10 (N = 1959) . | MUD 9/10 (N = 549) . | UCB (N = 333) . | Haplo (N = 193) . | |||||
| Graft failure | P < .001 | |||||||||
| No. of patients | 53 | 2% | 29 | 1% | 20 | 4% | 30 | 9% | 11 | 6% |
| Time to engraftment, d | P < .001 | |||||||||
| Median | 16 | 17 | 17 | 23 | 18 | |||||
| IQ range | 13-20 | 14-20 | 14-20 | 17-30 | 15-23 | |||||
| Acute GVHD (maximum grade) | P < .001 | |||||||||
| Grade 0-1 | 2623 | 75% | 1369 | 70% | 374 | 68% | 220 | 66% | 140 | 73% |
| Grade 2-4 | 769 | 22% | 518 | 26% | 156 | 28% | 99 | 30% | 49 | 25% |
| Unknown | 119 | 3% | 72 | 4% | 19 | 3% | 14 | 4% | 4 | 2% |
| Time transplant to acute GVHD, d | P < .11 | |||||||||
| Median | 28 | 27 | 25 | 28 | 29 | |||||
| IQR | 18-47 | 17-43 | 16-42 | 19-38 | 18-48 | |||||
| Chronic GVHD | P < .001 | |||||||||
| Mild | 533 | 15% | 283 | 14% | 81 | 15% | 28 | 8% | 39 | 20% |
| Extensive | 712 | 20% | 310 | 16% | 73 | 13% | 37 | 11% | 18 | 9% |
| Time transplant to chronic GVHD, mo | P < .001 | |||||||||
| Median | 6.0 | 5.4 | 5.6 | 4.9 | 6.4 | |||||
| IQ range | 4.0-9.6 | 3.7-8.3 | 3.7-8.3 | 4.1-6.9 | 4.1-9.6 | |||||
| Outcome at 2 y | ||||||||||
| OS | 59 ± 1% | 57 ± 1% | 49 ± 2% | 44 ± 3% | 57 ± 4% | |||||
| RFS | 53 ± 1% | 53 ± 1% | 44 ± 2% | 41 ± 3% | 52 ± 4% | |||||
| Relapse | 32 ± 1% | 27 ± 1% | 31 ± 2% | 30 ± 3% | 22 ± 3% | |||||
| NRM | 15 ± 1% | 20 ± 1% | 24 ± 2% | 29 ± 3% | 26 ± 3% | |||||