Clinical features of AML patient samples and quantified expression of CD123
Patient legend . | CD123 − IL-3 . | CD123 + IL-3 . | Age at dx (y) . | Sex . | FAB . | BM blast% . | WCC at dx (109/L) . | FLT3 mutation . | NPM1mutation . | Simple cytogenetics . | Detailed cytogenetics . |
---|---|---|---|---|---|---|---|---|---|---|---|
AML363 | NA | NA | 77 | M | M1 | 96 | 46.30 | FLT3-ITD | NPM1 | Normal | Normal |
AML266 | 157 | 204 | 55 | F | M4 | 39 | 67.10 | FLT3-ITD | Negative | Normal | Normal |
AML243 | 328 | 503 | 32 | M | M5 | 90 | 55 | Negative | Negative | t(9;11), 11q23, MLL | 46,XY,t(9;11)(p22;q23)[20] |
AML418 | NA | NA | 81 | M | M5 | 92 | 178 | Negative | Negative | ?MLL, -Y | 45,X,-Y,ins(11;10)(q23;p11.2p11.2)[18]/46,XY[3].ish ins(11;10)(5KMT2Adim+;3KMT2A+,5KMT2A+).nuc ish(5KMT2Ax3,3KMT2Ax2)(5KMT2A con 3KMT2A ×1)(5KMT2Adim con 3KMT2A ×1)[193/200] |
AML428 | 68 | 74 | 78 | M | M4 | 67 | 68.1 | Negative | Negative | der(11) | 47,XY,+der(11)(11pter->11p15::?::cen::?::11q14-22->11qter)[5]/46,XY[10].nuc ish(KMT2Ax4)[119/200] |
AML269 | 17 348 | 23 689 | 56 | M | M4 | 75 | 132 | FLT3-ITD | Negative | Normal | Normal |
AML057 | 163 | 216 | 64 | F | M5 | 36 | 43.3 | Negative | NPM1 | Normal | Normal |
AML264 | 1 333 | 1 763 | 64 | F | M1 | 100 | 111.1 | Negative | negative | del(16q) | 46,XX,del(16)(q22)[20].nuc ish(CBFBx1)[193/200] |
NA | 3 317 | 4 995 | 74 | M | NA | 22* | NA | Negative | negative | tri 14 | 47XY, +14 |
AML380 | 7 294 | 15 328 | 59 | F | M2 | 63 | 119 | FLT3-ITD | NPM1 | Normal | Normal |
AML419 | 1 807 | 1 577 | 56 | F | M1 | 89 | 57.10 | Negative | Negative | Normal | Normal |
AML101 | 7 294 | 15 328 | 48 | M | M1 | 99 | 98.10 | Negative | Negative | 46,XY,del(11)(q23)[20].ishdel(11)(5′MLL+,3′MLL-) | 46,XY,del(11)(q23)[20].ish del(11)(5′MLL+,3′MLL-) |
AML063 | NA | NA | 69 | F | M1 | 98 | 107.20 | FLT3-ITD | Negative | Normal | Normal |
AML427 | 111 | 257 | 59 | M | M5 | 72 | 8.68 | NA | NA | Normal | Normal |
AML379 | 857 | 339 | 63 | F | M1 | 90 | 35.20 | Negative | Negative | Normal | Normal |
AML235 | 3 100 | 3 195 | 28 | F | M2 | 73 | 18.30 | Negative | Negative | t(6;9) | 46,XX,t(6;9)(p23;q34) |
FL CD123-low (EV) | 277 | 292 | |||||||||
FL CD123-high-WT | 10 402 | 11 526 |
Patient legend . | CD123 − IL-3 . | CD123 + IL-3 . | Age at dx (y) . | Sex . | FAB . | BM blast% . | WCC at dx (109/L) . | FLT3 mutation . | NPM1mutation . | Simple cytogenetics . | Detailed cytogenetics . |
---|---|---|---|---|---|---|---|---|---|---|---|
AML363 | NA | NA | 77 | M | M1 | 96 | 46.30 | FLT3-ITD | NPM1 | Normal | Normal |
AML266 | 157 | 204 | 55 | F | M4 | 39 | 67.10 | FLT3-ITD | Negative | Normal | Normal |
AML243 | 328 | 503 | 32 | M | M5 | 90 | 55 | Negative | Negative | t(9;11), 11q23, MLL | 46,XY,t(9;11)(p22;q23)[20] |
AML418 | NA | NA | 81 | M | M5 | 92 | 178 | Negative | Negative | ?MLL, -Y | 45,X,-Y,ins(11;10)(q23;p11.2p11.2)[18]/46,XY[3].ish ins(11;10)(5KMT2Adim+;3KMT2A+,5KMT2A+).nuc ish(5KMT2Ax3,3KMT2Ax2)(5KMT2A con 3KMT2A ×1)(5KMT2Adim con 3KMT2A ×1)[193/200] |
AML428 | 68 | 74 | 78 | M | M4 | 67 | 68.1 | Negative | Negative | der(11) | 47,XY,+der(11)(11pter->11p15::?::cen::?::11q14-22->11qter)[5]/46,XY[10].nuc ish(KMT2Ax4)[119/200] |
AML269 | 17 348 | 23 689 | 56 | M | M4 | 75 | 132 | FLT3-ITD | Negative | Normal | Normal |
AML057 | 163 | 216 | 64 | F | M5 | 36 | 43.3 | Negative | NPM1 | Normal | Normal |
AML264 | 1 333 | 1 763 | 64 | F | M1 | 100 | 111.1 | Negative | negative | del(16q) | 46,XX,del(16)(q22)[20].nuc ish(CBFBx1)[193/200] |
NA | 3 317 | 4 995 | 74 | M | NA | 22* | NA | Negative | negative | tri 14 | 47XY, +14 |
AML380 | 7 294 | 15 328 | 59 | F | M2 | 63 | 119 | FLT3-ITD | NPM1 | Normal | Normal |
AML419 | 1 807 | 1 577 | 56 | F | M1 | 89 | 57.10 | Negative | Negative | Normal | Normal |
AML101 | 7 294 | 15 328 | 48 | M | M1 | 99 | 98.10 | Negative | Negative | 46,XY,del(11)(q23)[20].ishdel(11)(5′MLL+,3′MLL-) | 46,XY,del(11)(q23)[20].ish del(11)(5′MLL+,3′MLL-) |
AML063 | NA | NA | 69 | F | M1 | 98 | 107.20 | FLT3-ITD | Negative | Normal | Normal |
AML427 | 111 | 257 | 59 | M | M5 | 72 | 8.68 | NA | NA | Normal | Normal |
AML379 | 857 | 339 | 63 | F | M1 | 90 | 35.20 | Negative | Negative | Normal | Normal |
AML235 | 3 100 | 3 195 | 28 | F | M2 | 73 | 18.30 | Negative | Negative | t(6;9) | 46,XX,t(6;9)(p23;q34) |
FL CD123-low (EV) | 277 | 292 | |||||||||
FL CD123-high-WT | 10 402 | 11 526 |
dx, Diagnosis; F, female; M, male; NA, not available.
Diagnosis from PB blast percentage.