Significant SNPs in conditional meta-analysis in individual cohorts
| CHR . | GABC + TSS (N = 3238) . | GABC (n = 934) . | TSS (n = 2304) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP . | MAF . | βJ (%) . | SE (%) . | PJ . | MAF . | β (%) . | SE (%) . | P . | MAF . | β (%) . | SE (%) . | P . | |
| 9q34.2 | rs28673647 | 0.38 | 7.1 | 0.5 | 1.2E-57 | 0.36 | 6.9 | 1.0 | 8.1E-13 | 0.39 | 6.6 | 0.5 | 9.3E-42 |
| rs3739893 | 0.02 | −22.3 | 1.8 | 1.2E-30 | 0.01 | −15.6 | 4.7 | 1.7E-3 | 0.02 | −23.3 | 1.9 | 2.0E-28 | |
| 21q22.3 | rs4075970 | 0.45 | 2.4 | 0.4 | 6.8E-9 | 0.48 | 5.0 | 1.0 | 1.4E-7 | 0.44 | 1.4 | 0.5 | 4.6E-03 |
| 9q34.2 | rs3124762 | 0.16 | 3.5 | 0.6 | 8.9E-9 | 0.15 | −1.2 | 1.4 | .38 | 0.17 | 0.9 | 0.7 | .18 |
| CHR . | GABC + TSS (N = 3238) . | GABC (n = 934) . | TSS (n = 2304) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP . | MAF . | βJ (%) . | SE (%) . | PJ . | MAF . | β (%) . | SE (%) . | P . | MAF . | β (%) . | SE (%) . | P . | |
| 9q34.2 | rs28673647 | 0.38 | 7.1 | 0.5 | 1.2E-57 | 0.36 | 6.9 | 1.0 | 8.1E-13 | 0.39 | 6.6 | 0.5 | 9.3E-42 |
| rs3739893 | 0.02 | −22.3 | 1.8 | 1.2E-30 | 0.01 | −15.6 | 4.7 | 1.7E-3 | 0.02 | −23.3 | 1.9 | 2.0E-28 | |
| 21q22.3 | rs4075970 | 0.45 | 2.4 | 0.4 | 6.8E-9 | 0.48 | 5.0 | 1.0 | 1.4E-7 | 0.44 | 1.4 | 0.5 | 4.6E-03 |
| 9q34.2 | rs3124762 | 0.16 | 3.5 | 0.6 | 8.9E-9 | 0.15 | −1.2 | 1.4 | .38 | 0.17 | 0.9 | 0.7 | .18 |
β, percentage change per allele; CHR, chromosome; J, joint effects of independently associated SNPs; N or n, number of individuals in the indicated study cohort(s); SE, standard error.