Table 1.

Demographic characteristics and laboratory parameters of patients receiving rituximab prophylaxis for all 76 patients in total and 4 dose subgroups

CharacteristicTotal (N = 76)Standard dose (375 mg/m2 × 4) (n = 24)Reduced dose (200 mg × 4) (n = 19)Intermediate dose (500 mg × 4) (n = 17)Other doses (n = 16)
Female:male 60:16 17:7 15:4 13:4 14:2 
Median age (range), y 43.5 (18-78) 41 (24-67) 41 (18-74) 46 (29-78) 47 (19-65) 
Median Hb (range), g/L 133 (81*-171) 135 (96-171) 139 (81*-152) 140 (123-163) 125 (101-149) 
Median platelets (range), × 109/L 268 (83-443) 228 (109-333) 287 (150-397) 286 (199-443) 306 (83-390) 
Median ADAMTS13 activity (range), % 5 (<5-17) <5 (<5-16) 6 (<5-14) 6 (<5-15) 7 (<5-17) 
CharacteristicTotal (N = 76)Standard dose (375 mg/m2 × 4) (n = 24)Reduced dose (200 mg × 4) (n = 19)Intermediate dose (500 mg × 4) (n = 17)Other doses (n = 16)
Female:male 60:16 17:7 15:4 13:4 14:2 
Median age (range), y 43.5 (18-78) 41 (24-67) 41 (18-74) 46 (29-78) 47 (19-65) 
Median Hb (range), g/L 133 (81*-171) 135 (96-171) 139 (81*-152) 140 (123-163) 125 (101-149) 
Median platelets (range), × 109/L 268 (83-443) 228 (109-333) 287 (150-397) 286 (199-443) 306 (83-390) 
Median ADAMTS13 activity (range), % 5 (<5-17) <5 (<5-16) 6 (<5-14) 6 (<5-15) 7 (<5-17) 
*

Patient had low hemoglobin (Hb) because of coexisting iron deficiency anemia with no features of acute TTP.

Patient had a subacute TTP relapse.

Patient with platelets 109 × 109/L as a result of platelet clumping (evident on a blood film) with no features of microangiopathic hemolytic anemia.

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