Table 1. Candidate InO doses and... | American Society of Hematology

Table 1.

Candidate InO doses and schedules

Dose level	Dosing Schedule,* mg/m²				Total dose per cycle, mg/m²
Dose level	Day 1	Day 8	Day 15	Day 21	Total dose per cycle, mg/m²
−2	0.4	0	0.4	BM evaluation performed for disease assessment	0.8
−1	0.6	0	0.4	BM evaluation performed for disease assessment	1.0
1	0.8	0	0.4	BM evaluation performed for disease assessment	1.2
2	0.8	0.4	0.4	BM evaluation performed for disease assessment	1.6
3	0.8	0.5	0.5	BM evaluation performed for disease assessment	1.8
4	1.0	0.5	0.5	BM evaluation performed for disease assessment	2.0

Dose level	Dosing Schedule,* mg/m²				Total dose per cycle, mg/m²
Dose level	Day 1	Day 8	Day 15	Day 21	Total dose per cycle, mg/m²
−2	0.4	0	0.4	BM evaluation performed for disease assessment	0.8
−1	0.6	0	0.4	BM evaluation performed for disease assessment	1.0
1	0.8	0	0.4	BM evaluation performed for disease assessment	1.2
2	0.8	0.4	0.4	BM evaluation performed for disease assessment	1.6
3	0.8	0.5	0.5	BM evaluation performed for disease assessment	1.8
4	1.0	0.5	0.5	BM evaluation performed for disease assessment	2.0

Each cycle was 28 d (≤6 cycles).