Table 1. EMR during the first 5 years... | American Society of Hematology

Table 1.

EMR during the first 5 years after DLBCL diagnosis

	Model without therapy (model 1)			Model with therapy
	Model without therapy (model 1)			Adjusted for primary therapy (model 2)			Adjusted for primary therapy and immunotherapy (model 3)
	EMR*	95% CI	P†	EMR*	95% CI	P†	EMR*	95% CI	P†
Period of diagnosis
1989-2002	1.03	0.93-1.14	.554	1.02	0.92-1.13	.761	0.92	0.83-1.01	.086
2003-2007	1	(ref)		1	(ref)		1	(ref)
2008-2015	0.74	0.67-0.82	<.001	0.79	0.71-0.88	<.001	0.98	0.88-1.09	.709
Sex
Male	1	(ref)		1	(ref)		1	(ref)
Female	1.09	1.00-1.18	.046	1.00	0.92-1.08	.926	1.00	0.92-1.08	.929
Age at diagnosis, y
80-84	1	(ref)		1	(ref)		1	(ref)
85-89	1.43	1.31-1.56	<.001	1.03	0.94-1.12	.512	1.00	0.92-1.09	.962
≥90	1.48	1.29-1.70	<.001	1.00	0.88-1.15	.956	0.98	0.86-1.13	.797
Stage
1	1	(ref)		1	(ref)		1	(ref)
2	1.55	1.36-1.77	<.001	1.58	1.38-1.80	<.001	1.56	1.37-1.78	<.001
3	2.33	2.04-2.66	<.001	2.23	1.94-2.56	<.001	2.21	1.93-2.54	<.001
4	2.81	2.50-3.17	<.001	2.41	2.13-2.73	<.001	2.44	2.16-2.77	<.001
Unknown	3.72	3.23-4.47	<.001	2.00	1.74-2.31	<.001	1.95	1.69-2.24	<.001

	Model without therapy (model 1)			Model with therapy
	Model without therapy (model 1)			Adjusted for primary therapy (model 2)			Adjusted for primary therapy and immunotherapy (model 3)
	EMR*	95% CI	P†	EMR*	95% CI	P†	EMR*	95% CI	P†
Period of diagnosis
1989-2002	1.03	0.93-1.14	.554	1.02	0.92-1.13	.761	0.92	0.83-1.01	.086
2003-2007	1	(ref)		1	(ref)		1	(ref)
2008-2015	0.74	0.67-0.82	<.001	0.79	0.71-0.88	<.001	0.98	0.88-1.09	.709
Sex
Male	1	(ref)		1	(ref)		1	(ref)
Female	1.09	1.00-1.18	.046	1.00	0.92-1.08	.926	1.00	0.92-1.08	.929
Age at diagnosis, y
80-84	1	(ref)		1	(ref)		1	(ref)
85-89	1.43	1.31-1.56	<.001	1.03	0.94-1.12	.512	1.00	0.92-1.09	.962
≥90	1.48	1.29-1.70	<.001	1.00	0.88-1.15	.956	0.98	0.86-1.13	.797
Stage
1	1	(ref)		1	(ref)		1	(ref)
2	1.55	1.36-1.77	<.001	1.58	1.38-1.80	<.001	1.56	1.37-1.78	<.001
3	2.33	2.04-2.66	<.001	2.23	1.94-2.56	<.001	2.21	1.93-2.54	<.001
4	2.81	2.50-3.17	<.001	2.41	2.13-2.73	<.001	2.44	2.16-2.77	<.001
Unknown	3.72	3.23-4.47	<.001	2.00	1.74-2.31	<.001	1.95	1.69-2.24	<.001

EMR, excess mortality ratio; ref, reference.

Each covariate is simultaneously adjusted for all other covariates in the table, along with 5 years of follow-up.

P values are compared with the reference category.