Characteristics of adults with SCD and African American control participants
| Median (IQR), n (%), yes . | Control participants (n = 26) . | Adults with SCD (n = 71) . | P . |
|---|---|---|---|
| Demographics | |||
| Age, median years (range) | 28.3 (18.8-55.0) | 31.8 (19.7-63.2) | .07 |
| Female, n (%) | 15 (57.7) | 45 (63.3) | .61 |
| PFTs | |||
| FEV1, % predicted | 98.5 (90.0-106.0) | 81.0 (72.0-91.0) | <.0001 |
| No. of FEV1 (<5% LLN) | 1 (4.2) | 19 (27.5) | .019 |
| FVC, % predicted | 103.5 (94.0-111.0) | 85.0 (75.0-99.0) | <.0001 |
| No. of FVC (<5% LLN) | 0 | 16 (23.2) | .009 |
| FEV1/FVC, % predicted | 80.5 (76.0-84.0) | 78.0 (73.5-82.5) | .23 |
| No. of FEV1/FVC (<5% LLN) | 1 (3.9) | 6 (8.7) | .67 |
| TLC, % predicted | 107.0 (99.0-111.0) | 90.0 (81.0-103.0) | .004 |
| No. of TLC (<5% LLN) | 2 (8.7) | 32 (46.4) | .001 |
| DLCO, % predicted, hemoglobin adjusted | 79.9 (70.3-85.5) | 49.3 (41.4-57.7) | <.0001 |
| No. of DLCO (<80%) | 12 (50.0) | 68 (97.1) | <.0001 |
| PFT interpretation pattern, % | .12 | ||
| Normal | 23 (95.8) | 50 (72.5) | |
| Obstructive | 1 (4.2) | 4 (5.8) | |
| Restrictive | 0 | 12 (17.4) | |
| Mixed | 0 | 2 (2.9) | |
| Nonspecific | 0 | 1 (1.5) | |
| HRCT | |||
| No. with HRCT score ≥2 (%) | — | 11 (15.9) | — |
| Echocardiography | |||
| TR maximum velocity, cm/s | — | 228.0 (215.7-266.4) | — |
| Laboratory values | |||
| Hemoglobin, g/dL | 13.2 (12.4-13.9) | 9.5 (8.5-10.5) | <.0001 |
| WBC, ×109/L | 5.1 (4.1-6.9) | 8.6 (6.4-11.0) | <.0001 |
| Reticulocytes, % | 1.2 (1.-0-1.8) | 6.9 (3.3-9.8) | <.0001 |
| Resting SpO2, % | — | 98.0 (96.0-99.0) | — |
| 6-min walk test, m | — | 375.5 (330.0-417.5) | — |
| Fetal hemoglobin, % | — | 7.6 (2.2-15.7) | — |
| SCD characteristics | |||
| Pain length, cm | — | 2.4 (0.8-4.6) | — |
| History of ACS | — | 11 (15.5) | — |
| Hydroxyurea | — | 51 (71.8) | — |
| Transfusion in last 120 d, % | — | 14 (19.7) | — |
| Asthma characteristics | |||
| Asthma | — | 28 (39.4) | — |
| Eosinophils, % | 2.0 (1.0-2.5) | 2.0 (1.0-3.0) | >.9 |
| Median (IQR), n (%), yes . | Control participants (n = 26) . | Adults with SCD (n = 71) . | P . |
|---|---|---|---|
| Demographics | |||
| Age, median years (range) | 28.3 (18.8-55.0) | 31.8 (19.7-63.2) | .07 |
| Female, n (%) | 15 (57.7) | 45 (63.3) | .61 |
| PFTs | |||
| FEV1, % predicted | 98.5 (90.0-106.0) | 81.0 (72.0-91.0) | <.0001 |
| No. of FEV1 (<5% LLN) | 1 (4.2) | 19 (27.5) | .019 |
| FVC, % predicted | 103.5 (94.0-111.0) | 85.0 (75.0-99.0) | <.0001 |
| No. of FVC (<5% LLN) | 0 | 16 (23.2) | .009 |
| FEV1/FVC, % predicted | 80.5 (76.0-84.0) | 78.0 (73.5-82.5) | .23 |
| No. of FEV1/FVC (<5% LLN) | 1 (3.9) | 6 (8.7) | .67 |
| TLC, % predicted | 107.0 (99.0-111.0) | 90.0 (81.0-103.0) | .004 |
| No. of TLC (<5% LLN) | 2 (8.7) | 32 (46.4) | .001 |
| DLCO, % predicted, hemoglobin adjusted | 79.9 (70.3-85.5) | 49.3 (41.4-57.7) | <.0001 |
| No. of DLCO (<80%) | 12 (50.0) | 68 (97.1) | <.0001 |
| PFT interpretation pattern, % | .12 | ||
| Normal | 23 (95.8) | 50 (72.5) | |
| Obstructive | 1 (4.2) | 4 (5.8) | |
| Restrictive | 0 | 12 (17.4) | |
| Mixed | 0 | 2 (2.9) | |
| Nonspecific | 0 | 1 (1.5) | |
| HRCT | |||
| No. with HRCT score ≥2 (%) | — | 11 (15.9) | — |
| Echocardiography | |||
| TR maximum velocity, cm/s | — | 228.0 (215.7-266.4) | — |
| Laboratory values | |||
| Hemoglobin, g/dL | 13.2 (12.4-13.9) | 9.5 (8.5-10.5) | <.0001 |
| WBC, ×109/L | 5.1 (4.1-6.9) | 8.6 (6.4-11.0) | <.0001 |
| Reticulocytes, % | 1.2 (1.-0-1.8) | 6.9 (3.3-9.8) | <.0001 |
| Resting SpO2, % | — | 98.0 (96.0-99.0) | — |
| 6-min walk test, m | — | 375.5 (330.0-417.5) | — |
| Fetal hemoglobin, % | — | 7.6 (2.2-15.7) | — |
| SCD characteristics | |||
| Pain length, cm | — | 2.4 (0.8-4.6) | — |
| History of ACS | — | 11 (15.5) | — |
| Hydroxyurea | — | 51 (71.8) | — |
| Transfusion in last 120 d, % | — | 14 (19.7) | — |
| Asthma characteristics | |||
| Asthma | — | 28 (39.4) | — |
| Eosinophils, % | 2.0 (1.0-2.5) | 2.0 (1.0-3.0) | >.9 |
Bold indicates significance (P < .05).
IQR, interquartile range; LLN, lower limit of normal; SpO2, blood oxygen saturation; TR, tricuspid regurgitation; WBC, white blood cell count.